Khattak Mohammed, Pu Fanrong, Curran Judith M, Hunt John A, D'Sa Raechelle A
Centre for Materials and Structures, University of Liverpool, Brownlow Hill, Liverpool, L69 3GH, UK.
J Mater Sci Mater Med. 2015 May;26(5):178. doi: 10.1007/s10856-015-5507-2. Epub 2015 Apr 17.
Advances in material sciences have enabled the fabrication of biomaterials which are able to provide the requisite cues to stimulate cells to behave in a specific way. Nanoscale surface topographies are well known to be able to positively influence cell-substrate interactions. This study reports on a novel series of poly(ε-caprolactone) PCL and poly(methyl methacrylate) demixed nanotopographic films as non-biological cell-stimulating cues. The topographic features observed ranged from nanoislands to nanopits. PMMA was observed to segregate to the air interface, while PCL preferred the substrate interface. Preliminary response of human mesenchymal stem cells to these surfaces indicated that the substrate with nanoisland topography has the potential to differentiate to osteogenic, chondrogenic and adipogenic lineages.
材料科学的进展使得生物材料的制造成为可能，这些生物材料能够提供必要的信号来刺激细胞以特定方式表现。众所周知，纳米级表面形貌能够对细胞与基质的相互作用产生积极影响。本研究报道了一系列新型的聚（ε-己内酯）（PCL）和聚（甲基丙烯酸甲酯）相分离纳米形貌薄膜，作为非生物细胞刺激信号。观察到的形貌特征范围从纳米岛到纳米坑。观察到PMMA会偏析到空气界面，而PCL则更倾向于基质界面。人间充质干细胞对这些表面的初步反应表明，具有纳米岛形貌的基质具有分化为成骨、软骨生成和脂肪生成谱系的潜力。
