Nanotechnology Center for Mechanics in Regenerative Medicine, Department of Applied Physics and Applied Mathematics, Columbia University, New York, NY, USA.
Nanomedicine. 2010 Oct;6(5):619-33. doi: 10.1016/j.nano.2010.01.009. Epub 2010 Feb 4.
As materials technology and the field of biomedical engineering advances, the role of cellular mechanisms, in particular adhesive interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device design has evolved from the exquisite ability of biological systems to respond to topographical features or chemical stimuli, a process that has led to the development of next-generation biomaterials for a wide variety of clinical disorders. In vitro studies have identified nanoscale features as potent modulators of cellular behavior through the onset of focal adhesion formation. The focus of this review is on the recent developments concerning the role of nanoscale structures on integrin-mediated adhesion and cellular function with an emphasis on the generation of medical constructs with regenerative applications.
In this review, recent developments related to the role of nanoscale structures on integrin-mediated adhesion and cellular function is discussed, with an emphasis on regenerative applications.
随着材料技术和生物医学工程领域的进步，细胞机制的作用，特别是与植入式设备的黏附相互作用，在研究和临床实践中变得更加相关。医疗器械设计的一个关键原则是从生物系统对形貌特征或化学刺激的精细响应能力演变而来，这一过程导致了新一代生物材料的发展，可用于治疗各种临床疾病。体外研究已经确定纳米级特征是通过黏着斑形成来调节细胞行为的有力因素。本篇综述的重点是关于纳米结构在整合素介导的黏附和细胞功能方面的最新进展，重点是生成具有再生应用的医疗构建体。
在这篇综述中，讨论了纳米结构在整合素介导的黏附和细胞功能方面的最新发展，重点是再生应用。
