Stulajterova Radoslava, Medvecky Lubomir, Giretova Maria, Sopcak Tibor
Institute of Materials Research of SAS, Watsonova 47, 04001, Kosice, Slovakia.
J Mater Sci Mater Med. 2015 May;26(5):183. doi: 10.1007/s10856-015-5511-6. Epub 2015 Apr 17.
Biphasic porous calcium phosphate ceramics was prepared by sintering of transformed tetracalcium phosphate-monetite cement. After annealing hydroxyapatite, β- or α-TCP were found as main phases in ceramic substrates and a highly microporous microstructure of cement ceramics was created without an addition of porosifier. The origin microstructure features characteristic by the presence of hollow particle agglomerates in cement were preserved in microstructure of cement ceramics after annealing but the hydroxyapatite particles rose in size up to 2 µm and obtained a more regular shape. A small decrease in compressive strength was demonstrated in ceramics sintered up to 1150 °C and enhanced osteoblast proliferation was revealed on cement ceramic substrates in comparison with cement sample and conventional ceramics. The ALP activity of osteoblasts decreased with rise in sintering temperature. The prepared cement microporous ceramics could be utilized as carrier for antibiotics, drugs, growth factors, enzymes or other substances stimulating healing process.
通过转化的磷酸四钙-透钙磷石水泥烧结制备了双相多孔磷酸钙陶瓷。对羟基磷灰石进行退火处理后，在陶瓷基体中发现β-或α-TCP作为主要相，并且在不添加造孔剂的情况下形成了水泥陶瓷的高度微孔微观结构。水泥中原有的微观结构特征（以水泥中存在空心颗粒团聚体为特征）在退火后的水泥陶瓷微观结构中得以保留，但羟基磷灰石颗粒尺寸增大至2μm，并获得了更规则的形状。在高达1150°C烧结的陶瓷中，抗压强度略有下降，与水泥样品和传统陶瓷相比，在水泥陶瓷基体上显示出增强的成骨细胞增殖。成骨细胞的碱性磷酸酶活性随烧结温度的升高而降低。所制备的水泥微孔陶瓷可用作抗生素、药物、生长因子、酶或其他刺激愈合过程的物质的载体。
