Bozkurt Ozlem, Eras Zeynep, Canpolat Fuat Emre, Oguz Serife Suna, Uras Nurdan, Dilmen Ugur
a Department of Neonatology and.
b Department of Developmental Behavioral Pediatrics , Zekai Tahir Burak Maternity Teahing Hospital , Ankara , Turkey.
J Matern Fetal Neonatal Med. 2016;29(7):1101-4. doi: 10.3109/14767058.2015.1035641. Epub 2015 Apr 20.
Previous studies demonstrated that magnesium sulfate is associated with better neurological outcome and decreased cerebral palsy rates in preterm newborns. The aim of this study is to assess the effects of antenatal magnesium sulfate on neurodevelopmental outcomes of preterm infants.
Preterm newborns with a gestational age of <32 weeks whose mothers were diagnosed with preeclampsia were extracted from the hospital records and files retrospectively. The neurodevelopmental assessment was performed at 2 years of age by developmental pediatrician. The results of the infants exposed to antenatal magnesium sulfate were compared with the control group.
Between the years 2010 and 2012, 387 preterm babies were born to preeclamptic mothers. Fifty-nine (15.2%) of them were exposed to antenatal magnesium sulfate. The main clinical characteristics did not differ between the groups. On the other hand, cerebral palsy was significantly lower in preterm infants exposed to magnesium sulfate compared to the control group (3.3% and 12.2%, respectively, p = 0.004). On multinominal logistic regression analysis, magnesium sulfate was not an independent significant factor to reduce CP on its own.
Antenatal magnesium sulfate can be used as a neuroprotective strategy especially for the prevention of cerebral palsy in preterm infants. Future studies should be designed to support the positive effect of antenatal magnesium sulfate on neurologic development.
先前的研究表明，硫酸镁与早产新生儿更好的神经学预后及降低脑瘫发生率相关。本研究的目的是评估产前硫酸镁对早产儿神经发育结局的影响。
回顾性地从医院记录和档案中提取孕周<32周且母亲被诊断为子痫前期的早产新生儿。在2岁时由发育儿科医生进行神经发育评估。将暴露于产前硫酸镁的婴儿的结果与对照组进行比较。
在2010年至2012年期间，387名患有子痫前期的母亲生下了早产婴儿。其中59名（15.2%）暴露于产前硫酸镁。两组之间的主要临床特征没有差异。另一方面，与对照组相比，暴露于硫酸镁的早产儿脑瘫发生率显著更低（分别为3.3%和12.2%，p = 0.004）。在多项逻辑回归分析中，硫酸镁本身并不是降低脑瘫的独立显著因素。
产前硫酸镁可作为一种神经保护策略，尤其是用于预防早产儿脑瘫。未来的研究应设计以支持产前硫酸镁对神经发育的积极作用。
