Itoh Kanako, Maki Takakuni, Shindo Akihiro, Egawa Naohiro, Liang Anna C, Itoh Naoki, Lo Eng H, Lok Josephine, Arai Ken
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Neurosci Res. 2016 May;106:66-9. doi: 10.1016/j.neures.2015.12.004. Epub 2015 Dec 14.
Hypoxic-ischemic (HI) brain injury in newborns results in serious damage. Magnesium sulfate has been clinically used as a cyto-protective agent against HI brain injury in newborns in some countries, including Japan. However, it is not clear how magnesium exerts this effect and how it acts on the individual types of cells within the newborn brain. In this study, we exposed cultured rat oligodendrocyte precursor cells to magnesium sulfate during the period when they differentiate into oligodendrocytes, and showed that magnesium-exposed oligodendrocytes exhibited more resistance to HI injury. Our data may support the use of magnesium sulfate in the clinical setting.
新生儿缺氧缺血性（HI）脑损伤会导致严重损害。在包括日本在内的一些国家，硫酸镁已在临床上用作针对新生儿HI脑损伤的细胞保护剂。然而，尚不清楚镁是如何发挥这种作用的，以及它如何作用于新生大脑中的各类细胞。在本研究中，我们在培养的大鼠少突胶质前体细胞分化为少突胶质细胞的期间将其暴露于硫酸镁中，结果显示暴露于镁的少突胶质细胞对HI损伤表现出更强的抵抗力。我们的数据可能支持硫酸镁在临床环境中的应用。
