Rosenblum Michael D, Remedios Kelly A, Abbas Abul K
J Clin Invest. 2015 Jun;125(6):2228-33. doi: 10.1172/JCI78088. Epub 2015 Jun 1.
Autoimmune reactions reflect an imbalance between effector and regulatory immune responses, typically develop through stages of initiation and propagation, and often show phases of resolution (indicated by clinical remissions) and exacerbations (indicated by symptomatic flares). The fundamental underlying mechanism of autoimmunity is defective elimination and/or control of self-reactive lymphocytes. Studies in humans and experimental animal models are revealing the genetic and environmental factors that contribute to autoimmunity. A major goal of research in this area is to exploit this knowledge to better understand the pathogenesis of autoimmune diseases and to develop strategies for reestablishing the normal balance between effector and regulatory immune responses.
自身免疫反应反映了效应性免疫反应与调节性免疫反应之间的失衡，通常经历起始和传播阶段，且常表现出缓解期（以临床缓解为标志）和加重期（以症状发作加剧为标志）。自身免疫的根本潜在机制是对自身反应性淋巴细胞的清除和/或控制存在缺陷。对人类和实验动物模型的研究正在揭示导致自身免疫的遗传和环境因素。该领域研究的一个主要目标是利用这些知识更好地理解自身免疫性疾病的发病机制，并制定策略以重新建立效应性免疫反应与调节性免疫反应之间的正常平衡。
