Aydın M, Aydın S, Bacanlı M, Başaran N
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Hospital of Başkent University, Istanbul, Turkey.
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
J Viral Hepat. 2015 Nov;22(11):926-35. doi: 10.1111/jvh.12410. Epub 2015 Apr 20.
Aflatoxins, the secondary metabolites produced by species of naturally occurring Aspergilli, are commonly found in food such as cereals, dried fruits and juice, wine, beer and spices. They are hepatotoxic and are well known human carcinogens based on evidence from human studies. Aflatoxins are an environmental risk factor for the development of hepatocellular carcinoma (HCC). Chronic hepatitis B-infected patients are at increased risk of cirrhosis, hepatic failure and liver cancer. This study was designed to determine the serum aflatoxin B1 (AFB1 ), aflatoxin B2 (AFB2 ), aflatoxin G1 (AFG1 ) and aflatoxin G2 (AFG2 ) concentrations using high-pressure liquid chromatography (HPLC) in hepatitis B-infected patients with or without cirrhosis and liver cancer, alongside healthy controls in Balıkesir, Turkey. The mean AFB1 and total AF levels in patients without liver cancer and cirrhosis were significantly higher than healthy controls. The mean AFB1 and total AF levels in patients with chronic hepatitis B and HCC were significantly higher than infected patients with or without cirrhosis. These results suggest that patients with chronic hepatitis B who are exposed to AFs are at increased risk for developing HCC, which might be prevented by reducing consumption of contaminated foods.
黄曲霉毒素是由天然存在的曲霉菌种产生的次生代谢产物，常见于谷物、干果、果汁、葡萄酒、啤酒和香料等食物中。它们具有肝毒性，基于人体研究证据，是众所周知的人类致癌物。黄曲霉毒素是肝细胞癌（HCC）发生的一个环境风险因素。慢性乙型肝炎感染患者患肝硬化、肝衰竭和肝癌的风险增加。本研究旨在采用高压液相色谱法（HPLC）测定土耳其巴勒克埃西尔地区患有或未患有肝硬化和肝癌的乙型肝炎感染患者以及健康对照者血清中的黄曲霉毒素B1（AFB1）、黄曲霉毒素B2（AFB2）、黄曲霉毒素G1（AFG1）和黄曲霉毒素G2（AFG2）浓度。未患肝癌和肝硬化的患者中AFB1和总AF水平显著高于健康对照者。慢性乙型肝炎和HCC患者的AFB1和总AF水平显著高于患有或未患有肝硬化的感染患者。这些结果表明，接触AFs的慢性乙型肝炎患者患HCC的风险增加，减少食用受污染食物可能预防这种情况。
