Helmerhorst T J, Wijnen H J, Kenemans P, Tjioe G S, Dijkhuizen H H, Calame J J, Stolk H G
Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Am J Obstet Gynecol. 1989 Nov;161(5):1191-4. doi: 10.1016/0002-9378(89)90662-5.
Data from two regional diethylstilbestrol clinics for colposcopic evaluation of young women with a history of diethylstilbestrol exposure in utero are presented: A total of 224 subjects with a well-documented history were enrolled in this study. Structural anomalies of the cervix and vagina were found in 30%. Vaginal epithelial changes were colposcopically observed in 65%, including vaginal adenosis in 22%. The prevalence rate of abnormal cytologic findings in the study group was 9%. In half of these patients a low-grade intraepithelial neoplasia of the cervix and vagina was found. It was concluded that colposcopy in diethylstilbestrol-exposed offspring in inexperienced hands can result in many unnecessary biopsies. Therefore colposcopic examination should be performed by expert colposcopists in referral diethylstilbestrol centers.
本文呈现了来自两个地区己烯雌酚诊所的数据，这些数据是关于对有子宫内己烯雌酚暴露史的年轻女性进行阴道镜评估的情况：本研究共纳入了224名有充分记录病史的受试者。在30%的受试者中发现了宫颈和阴道的结构异常。阴道镜检查观察到65%的受试者有阴道上皮变化，其中22%有阴道腺病。研究组中细胞学检查异常结果的患病率为9%。在这些患者中，有一半被发现患有宫颈和阴道的低级别上皮内瘤变。得出的结论是，在经验不足的医生手中，对己烯雌酚暴露后代进行阴道镜检查可能会导致许多不必要的活检。因此，阴道镜检查应由己烯雌酚转诊中心的专业阴道镜医生进行。
