Scott J W
J Reprod Med. 1976 Jun;16(6):285-8.
The female offspring of DES-treated mothers are examined cytologically and colposcopically annually, starting at the age of seven years no treatment is indicated until a colposcopic atypical transformation zone occurs. With its occurrence all the abnormal epithelium(squamous or columnar) is excised from the vagina and cervix under colposcopic guidance in the hospital or in the office under local anesthesia. The procedures are done in stages to minimize scarring and to eliminate the possibility of vaginal-cervical adhesions or vaginal shortening. The finding of an incidence of 47% of cervical or vaginal intraepithelial neoplasia in 34 patients aged 10 to 26 years so treated to date indicates a high risk of potential candidacy for squamous carcinoma of the vagina or cervix in later years.
己烯雌酚暴露母亲的雌性后代从7岁起每年进行细胞学和阴道镜检查，在阴道镜下出现非典型转化区之前不进行治疗。一旦出现，在医院或门诊局部麻醉下，于阴道镜引导下从阴道和宫颈切除所有异常上皮组织（鳞状或柱状）。手术分阶段进行，以尽量减少瘢痕形成，并消除阴道宫颈粘连或阴道缩短的可能性。在目前接受治疗的34名年龄在10至26岁的患者中，宫颈或阴道上皮内瘤变的发生率为47%，这表明这些患者在晚年患阴道或宫颈癌的潜在风险很高。
