Stupina T A, Stepanov M A, Teplen'kii M P
G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia,
Bull Exp Biol Med. 2015 Apr;158(6):820-3. doi: 10.1007/s10517-015-2870-4. Epub 2015 Apr 21.
The role of subchondral bone in the restoration of the articular cartilage was determined in experiments on mongrel dogs subjected to gonarthrosis modeling followed by subchondral zone tunneling and introduction of bone marrow suspension into the canal. Light microscopy, computer histomorphometry, and electron probe microanalysis showed that stimulation of functional activity of chondrocytes was achieved via correction of homeostasis of the cartilage and subchondral bone and improvement of tissue trophic. Restoration of the microarchitecture of the subchondral bone and improving its vascularization after tunneling with the introduction of bone marrow suspension into the drill holes enhances chondrocyte metabolism and recovers their functionality.
在对患有膝关节炎模型的杂种犬进行实验中，通过对软骨下骨区域进行隧道钻孔并向管腔内引入骨髓悬液，研究了软骨下骨在关节软骨修复中的作用。光学显微镜、计算机组织形态计量学和电子探针微分析表明，通过纠正软骨和软骨下骨的内环境稳态以及改善组织营养，可实现对软骨细胞功能活性的刺激。在用骨髓悬液引入钻孔进行隧道钻孔后，恢复软骨下骨的微观结构并改善其血管化，可增强软骨细胞代谢并恢复其功能。
