Koopmann Anne, Bez Jennifer, Lemenager Tagrid, Hermann Derik, Dinter Christina, Reinhard Iris, Hoffmann Heiko, Wiedemann Klaus, Winterer Georg, Kiefer Falk
Ann Nutr Metab. 2015;66(2-3):155-161. doi: 10.1159/000381834. Epub 2015 Apr 18.
Weight gain is a common but only a partially understood consequence of smoking cessation. Existing data suggest modulating effects of the orexigenic peptide ghrelin on food intake. The aim of the present study was to investigate the effect of tobacco withdrawal on plasma concentration of acetylated and total ghrelin.
Fifty four normal-weighted smokers and 30 non-smoking healthy controls were enrolled in our study. Concentrations of acetylated and total ghrelin were measured in blood plasma drawn two hours after a standardized meal and three hours after the smokers smoked their last cigarette. The severity of tobacco addiction was assessed based on cotinine plasma concentration, the Fagerström Test for Nicotine Dependence (FTND) and the number of cigarettes smoked per day.
The plasma concentration of acetylated ghrelin, but not total ghrelin, was significantly higher in smokers than in non-smokers. Moreover, we found significant negative correlations between acetylated ghrelin and all measures of the severity of nicotine dependence.
Early abstinence from tobacco smoking seems to be associated with increased plasma concentration of the orexigenic peptide acetylated ghrelin. This could be one reason for increased food craving during nicotine withdrawal and subsequent weight gain. Smokers might compensate these effects by increasing tobacco intake.
体重增加是戒烟后常见但仅部分被理解的后果。现有数据表明促食欲肽胃饥饿素对食物摄入量有调节作用。本研究的目的是调查戒烟对乙酰化胃饥饿素和总胃饥饿素血浆浓度的影响。
54名体重正常的吸烟者和30名不吸烟的健康对照者参与了我们的研究。在标准化餐后两小时以及吸烟者吸最后一支烟三小时后采集的血浆中测量乙酰化胃饥饿素和总胃饥饿素的浓度。根据血浆可替宁浓度、尼古丁依赖的法格斯特罗姆测试（FTND）以及每天吸烟的数量评估烟草成瘾的严重程度。
吸烟者中乙酰化胃饥饿素的血浆浓度显著高于不吸烟者，而总胃饥饿素的血浆浓度则无显著差异。此外，我们发现乙酰化胃饥饿素与尼古丁依赖严重程度的所有指标之间存在显著的负相关。
早期戒烟似乎与促食欲肽乙酰化胃饥饿素的血浆浓度升高有关。这可能是尼古丁戒断期间食物渴望增加以及随后体重增加的一个原因。吸烟者可能通过增加烟草摄入量来补偿这些影响。
