抗菌药物通过激活鲍曼不动杆菌中的SOS反应在获得耐药性方面的不同作用。
Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii.
作者信息
Jara Luis M, Cortés Pilar, Bou Germán, Barbé Jordi, Aranda Jesús
机构信息
Departament de Genètica i Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
Servizo de Microbioloxía-INIBIC, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Spain.
出版信息
Antimicrob Agents Chemother. 2015 Jul;59(7):4318-20. doi: 10.1128/AAC.04918-14. Epub 2015 Apr 20.
Abstract
The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not.
摘要
抗菌药物对SOS介导的诱变诱导作用取决于细菌种类和抗菌药物类别。在本研究中，我们研究了临床治疗中使用的不同类别的抗菌药物对鲍曼不动杆菌这种多重耐药革兰氏阴性病原体诱变诱导的影响。数据表明，环丙沙星和四环素可诱导SOS介导的诱变，而临床治疗中广泛使用的黏菌素和美罗培南则不会。
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