Chen Liang, Al Laham Nahed, Chavda Kalyan D, Mediavilla Jose R, Jacobs Michael R, Bonomo Robert A, Kreiswirth Barry N
Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA Department of Laboratory Medicine, Al Azhar University-Gaza, Gaza, Palestine
Antimicrob Agents Chemother. 2015 Jul;59(7):4305-7. doi: 10.1128/AAC.00565-15. Epub 2015 Apr 20.
We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla(OXA-48)-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene bla(OXA-48), extended spectrum β-lactamase gene bla(CTX-M-14), and aminoglycoside resistance genes strA, strB, and aph(3')-VIb.
我们报告了在巴勒斯坦加沙的希法医院分离出的首例产碳青霉烯酶OXA-48的多重耐药奇异变形杆菌菌株(Pm-OXA-48)。Pm-OXA-48的基因组草图测序鉴定出16个抗菌耐药基因,编码对β-内酰胺类、氨基糖苷类、氟喹诺酮类、酚类、链丝菌素、四环素和甲氧苄啶-磺胺甲恶唑的耐药性。携带bla(OXA-48)质粒的完整测序显示,它是一个72 kb长的IncL/M质粒,携带碳青霉烯酶基因bla(OXA-48)、超广谱β-内酰胺酶基因bla(CTX-M-14)以及氨基糖苷类耐药基因strA、strB和aph(3')-VIb。