Detection of Carbapenem Resistance of Strains Isolated from Foxes, Raccoons and Minks in China.

, an opportunistic pathogen, is found to be an emerging threat to both animals and humans for a variety of infections. However, the characteristics of infections from foxes, raccoons and minks remain unclear. In this context, we identified the antibiotic resistance genes and virulence genes of isolates from foxes, raccoons and minks in China. Most isolates showed resistance to florfenicol (90.57%), trimethoprim-sulfamethoxazole (73.58%), and imipenem (71.70%). A total of 73.58% of isolates were resistant to antibiotics from at least three or more classes, and were categorized as multi-drug resistant. A total of 33.33% of the isolates were resistant to antibiotics from seven classes. The most prevalent resistant were (94.34%), followed by , , and with the detection rate of 88.68%, 83.02%, 71.70% and 60.38%, respectively. Among the 51 isolates that were resistant to beta-lactam antibiotics, all isolates carried at least one beta-lactam gene. In addition, and genes were firstly reported in carbapenem-resistant isolates from foxes, raccoons and minks. All isolates exhibited the virulence genes , , , and . isolates carrying all detected 10 virulence genes from different animal species showed different lethal abilities in a larvae model More importantly, the profiles of antibiotic resistance genes of isolates from fur animals and the environment were generally similar, and phylogenetic analysis showed that the isolates from farm environment samples may have close relatedness with that from animals.