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利妥昔单抗治疗继发的外阴阴道坏疽性脓皮病。

Vulvovaginal pyoderma gangrenosum secondary to rituximab therapy.

作者信息

Dixit Shreya, Selva-Nayagam Priya, Hamann Ian, Fischer Gayle

机构信息

1Northern Clinical School, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales; 2Royal Adelaide Hospital, Adelaide, South Australia; and 3Mid North Coast Dermatology, Port Macquarie, New South Wales, Australia.

出版信息

J Low Genit Tract Dis. 2015 Jan;19(1):e6-9. doi: 10.1097/LGT.0000000000000043.

DOI:10.1097/LGT.0000000000000043
PMID:24769650
Abstract

Rituximab is being used increasingly for the treatment of B-cell malignancies and nonmalignant conditions. Pyoderma gangrenosum is a rare neutrophilic dermatosis, which can be either idiopathic or associated with underlying systemic inflammatory conditions. We present a series of 4 patients who presented with ulcerative pyoderma gangrenosum in the vulvovaginal area after treatment with rituximab.

摘要

利妥昔单抗越来越多地用于治疗B细胞恶性肿瘤和非恶性疾病。坏疽性脓皮病是一种罕见的嗜中性皮病,可为特发性或与潜在的全身性炎症性疾病相关。我们报告了4例在接受利妥昔单抗治疗后出现外阴阴道溃疡性坏疽性脓皮病的患者。

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Vulvovaginal pyoderma gangrenosum secondary to rituximab therapy.利妥昔单抗治疗继发的外阴阴道坏疽性脓皮病。
J Low Genit Tract Dis. 2015 Jan;19(1):e6-9. doi: 10.1097/LGT.0000000000000043.
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Neutrophilic dermatoses: a review of current treatment options.嗜中性皮肤病:当前治疗选择综述
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引用本文的文献

1
Pyoderma gangrenosum controlled with rituximab.利妥昔单抗控制坏疽性脓皮病。
JAAD Case Rep. 2019 Jun 26;5(7):593-595. doi: 10.1016/j.jdcr.2019.04.019. eCollection 2019 Jul.
2
A case of rituximab-induced pyoderma gangrenosum.1例利妥昔单抗诱发的坏疽性脓皮病。
JAAD Case Rep. 2018 Oct 29;4(10):979-981. doi: 10.1016/j.jdcr.2018.09.003. eCollection 2018 Nov.
3
Improvement of Ulcerations in Treatment-Resistant Chronic Scarring in a Patient with Pyoderma Gangrenosum After Improving Vascular Insufficiency, Gently Removing Necrotic Debris, and Decreasing Wound Fluid.
在改善血管功能不全、轻柔清除坏死组织碎片并减少创面渗出液后,坏疽性脓皮病患者难治性慢性瘢痕溃疡情况得到改善。
Am J Case Rep. 2018 Jul 19;19:844-848. doi: 10.12659/AJCR.908995.
4
A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma.1例用环孢素成功治疗的坏疽性生殖器脓皮病,同时已确诊的滤泡性淋巴瘤未复发。
JAAD Case Rep. 2018 May 7;4(5):474-476. doi: 10.1016/j.jdcr.2018.01.004. eCollection 2018 Jun.
5
Rituximab causing deep ulcerative suppurative vaginitis/pyoderma gangrenosum.利妥昔单抗引发深部溃疡性化脓性阴道炎/坏疽性脓皮病。
Curr Infect Dis Rep. 2015 May;17(5):478. doi: 10.1007/s11908-015-0478-5.