Nagata Shunjiro, Kokado Kenta, Sada Kazuki
Department of Chemical Sciences and Engineering, Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, 060-0810, Japan.
Chem Commun (Camb). 2015 May 21;51(41):8614-7. doi: 10.1039/c5cc02339d.
A smart metal-organic framework (MOF) exhibiting controlled release was achieved by modification with a thermoresponsive polymer (PNIPAM) via a surface-selective post-synthetic modification technique. Simple temperature variation readily switches "open" (lower temperature) and "closed" (higher temperature) states of the polymer-modified MOF through conformational change of PNIPAM grafted onto the MOF, resulting in controlled release of the included guest molecules such as resorufin, caffeine, and procainamide.
通过表面选择性后合成修饰技术，用热响应聚合物（聚N-异丙基丙烯酰胺，PNIPAM）对智能金属有机框架（MOF）进行修饰，实现了可控释放。简单的温度变化通过接枝到MOF上的PNIPAM的构象变化，很容易切换聚合物修饰的MOF的“开放”（较低温度）和“封闭”（较高温度）状态，从而实现对诸如试卤灵、咖啡因和普鲁卡因酰胺等包合客体分子的可控释放。
