Trzeciak-Ryczek Alicja, Tokarz-Deptuła Beata, Deptuła Wiesław
Department of Immunology, Faculty of Biology, University of Szczecin, Szczecin, Poland.
Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland.
Postepy Hig Med Dosw (Online). 2015 Apr 9;69:469-74. doi: 10.5604/17322693.1148747.
Fungi are omnipresent in the environment; hence they are frequent factors causing infections in humans and animals even if their immune system works correctly. These facts stimulated interest in and the will to understand the antifungal immunity mechanisms. It has been, however, evidenced that the immunological response to mycotic pathogens is related to the species and morphological form of the fungus. Nevertheless, it is assumed that always in the antifungal response, there are mechanisms of innate and adaptive immunity that cooperate with one another to eliminate such pathogens. It has been evidenced that the main elements of antifungal immunity are physical barriers of the organism, phagocytosis, cytotoxicity, and possibly trogocytosis of PMN and MN cells, as well as T-cells, and to a smaller extent B-cells, the proportion of which is principally related to their products activating the processes of PMN and MN cells. An important role in this immunity also belongs to PRR, which activate the main processes of phagocytosis and cytotoxicity of PMN, MN, NK and DC cells.
真菌在环境中无处不在；因此，即使人类和动物的免疫系统正常运作，它们仍是导致人类和动物感染的常见因素。这些事实激发了人们对抗真菌免疫机制的兴趣和理解意愿。然而，已有证据表明，对真菌病原体的免疫反应与真菌的种类和形态有关。尽管如此，人们认为在抗真菌反应中，固有免疫和适应性免疫机制总是相互协作以清除此类病原体。已有证据表明，抗真菌免疫的主要要素包括机体的物理屏障、吞噬作用、细胞毒性，以及PMN和MN细胞、T细胞可能的反吞噬作用，还有程度较小的B细胞，其比例主要与其激活PMN和MN细胞过程的产物有关。PRR在这种免疫中也起着重要作用，它激活PMN、MN、NK和DC细胞的主要吞噬和细胞毒性过程。
