Kuwabara Hiroyo, Saito Yoshimichi, Mahlich Jörg
Health Economics, Janssen KK, Tokyo, Japan.
Health Economics, Janssen KK, Tokyo, Japan ; Düsseldorf Institute for Competition Economics, University of Düsseldorf, Düsseldorf, Germany.
Neuropsychiatr Dis Treat. 2015 Apr 1;11:935-40. doi: 10.2147/NDT.S81677. eCollection 2015.
The aim of this study is to analyze if there is a relationship between adherence to antipsychotic medication and rehospitalization for patients diagnosed with schizophrenia in Japan.
Based on Japanese claims data, we constructed three patient groups based on their medication possession ratio (MPR). Controlling for potential confounders, a Cox proportional hazard model was employed to assess if medication adherence affects the risk of rehospitalization.
Patients with good adherence (MPRs from 0.8-1.1) had the lowest rates of admission. Both poor adherence (MPRs <0.8) and overadherence (MPRs >1.1) were associated with a significant higher risk of rehospitalization with hazard ratios of 4.7 and 2.0, respectively.
The results of this study support the notion that good adherence to antipsychotic medication reduces the risk of rehospitalization of schizophrenia patients. Appropriate measures should be taken to improve adherence of schizophrenia patients.
本研究旨在分析日本精神分裂症患者的抗精神病药物依从性与再次住院之间是否存在关联。
基于日本的医保报销数据，我们根据药物持有率（MPR）构建了三组患者。在控制潜在混杂因素的情况下，采用Cox比例风险模型评估药物依从性是否会影响再次住院的风险。
依从性良好（MPR为0.8 - 1.1）的患者住院率最低。依从性差（MPR < 0.8）和依从性过高（MPR > 1.1）均与再次住院的显著更高风险相关，风险比分别为4.7和2.0。
本研究结果支持以下观点，即良好的抗精神病药物依从性可降低精神分裂症患者再次住院的风险。应采取适当措施提高精神分裂症患者的依从性。
