Lohr W David, Chowning Russell T, Stevenson Michelle D, Williams Patricia Gail
Department of Pediatrics, University of Louisville School of Medicine , Louisville, Kentucky.
J Child Adolesc Psychopharmacol. 2015 Jun;25(5):440-3. doi: 10.1089/cap.2014.0057. Epub 2015 Apr 21.
Studies have shown an increase in the use of antipsychotics to preschoolers for disruptive behavior and aggression. This study investigated the use of atypical antipsychotics in children ≤6 years of age in Kentucky who were on Medicaid.
Kentucky Medicaid prescription claims data between 2001 and 2010 were examined for all children ≤6 years of age who had received an atypical antipsychotic. Drug type, diagnosis codes, and geographic trends were analyzed using descriptive statistics.
A total of 70,777 prescriptions were written to 6915 distinct children ≤6 years of age. The use of atypical antipsychotics in this age group increased over the years 2001-2010 with a peak ∼ 1.0% in 2004, and averaged 0.75% in 2010. Older male children were more likely to receive atypical antipsychotics, and risperidone accounted for two thirds of the prescriptions written. Mood disorders, primarily bipolar disorder, accounted for almost 75% of the diagnoses provided. Only 32% of the prescriptions were written by child psychiatrists. Geographic analysis showed significantly higher use in the Western part of the state (more than three times the state mean in some counties).
The use of atypical antipsychotics in children ≤6 years of age has declined from its peak, but remains substantial. The prescription rates for atypical antipsychotics by providers other than child psychiatrists, and the marked geographic variation in use across the state of Kentucky suggest that improved systems of mental healthcare for this population are needed.
研究表明,用于治疗学龄前儿童破坏性行为和攻击行为的抗精神病药物使用量有所增加。本研究调查了肯塔基州医疗补助计划覆盖的6岁及以下儿童使用非典型抗精神病药物的情况。
对2001年至2010年间肯塔基州医疗补助计划的处方索赔数据进行检查,以了解所有6岁及以下接受过非典型抗精神病药物治疗的儿童情况。使用描述性统计分析药物类型、诊断代码和地理趋势。
共为6915名不同的6岁及以下儿童开具了70777份处方。2001年至2010年间,该年龄组非典型抗精神病药物的使用量有所增加,2004年达到峰值约1.0%,2010年平均为0.75%。年龄较大的男性儿童更有可能接受非典型抗精神病药物治疗,其中利培酮占所开处方的三分之二。情绪障碍,主要是双相情感障碍,占所提供诊断病例的近75%。只有32%的处方由儿童精神科医生开具。地理分析显示该州西部的使用量显著更高(某些县超过该州平均水平的三倍)。
6岁及以下儿童非典型抗精神病药物的使用量已从峰值下降,但仍然可观。儿童精神科医生以外的医疗服务提供者开具非典型抗精神病药物的处方率,以及肯塔基州各地使用情况的显著地理差异表明,需要改善该人群的精神卫生保健系统。