Isella Valeria, Molteni Federica, Mapelli Cristina, Ferrarese Carlo
DSTM, Milan Centre for Neurosciences, University of Milano Bicocca, Italy; Neurology Unit, San Gerardo Hospital, Monza, Italy.
Department of Neurological Sciences and Movement, University of Verona, Italy.
Brain Cogn. 2015 Jun;96:38-42. doi: 10.1016/j.bandc.2015.02.002. Epub 2015 Apr 19.
In the present study we replicated a previous experiment investigating visuo-spatial short term memory binding in young and older healthy individuals, in the attempt to verify the pattern of impairment that can be observed in normal elderly for short term memory for single items vs short term memory for bindings. Assessing a larger sample size (25 young and 25 older subjects), using a more appropriate measure of accuracy for a change detection task (A'), and adding the evaluation of speed of performance, we confirmed that old normals show a decline in short term memory for bindings of shape and colour that is of comparable extent, and not major, to the decline in memory for single shapes and single colours. The absence of a specific deficit of short term memory for conjunctions of surface features seems to distinguish cognitive ageing from Alzheimer's Disease.
在本研究中，我们重复了之前一项针对年轻和老年健康个体视觉空间短期记忆绑定的实验，旨在验证在正常老年人中，单项短期记忆与绑定短期记忆相比可能观察到的损伤模式。通过评估更大的样本量（25名年轻受试者和25名老年受试者），使用更适合变化检测任务的准确性测量方法（A'），并增加对表现速度的评估，我们证实老年正常人在形状和颜色绑定的短期记忆方面的下降程度与单个形状和单个颜色的记忆下降程度相当，且并非更严重。表面特征结合的短期记忆不存在特定缺陷，这似乎是认知衰老与阿尔茨海默病的区别所在。
