Mulla Zuber D, Carrillo Thelma, Kalamegham Ramaswami, Hernandez Loretta L, Portugal Elizabeth, Nuwayhid Bahij S
J Reprod Med. 2015 Mar-Apr;60(3-4):117-26.
To explore the association between maternal rectovaginal colonization with group B Streptococcus (GBS) and the outcome of preeclampsia, and to identify other factors such as maternal chocolate consumption that may be associated with preeclampsia on the Texas-Mexico border.
A case-control study was conducted among 330 women who delivered at a teaching hospital in El Paso, Texas, during the time period April 2010 to April 2012. Preeclamptic cases (n = 165) and controls free of preeclampsia (n = 165) were matched by gestational age and date of delivery. Conditional logistic regression (with multiple imputation for missing data) was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) that were adjusted for maternal age and other factors.
Cases (94.6%) and controls (97.0%) were predominantly Hispanic. GBS colonization was not associated with preeclampsia: adjusted OR = 1.73 (95% CI 0.63-4.74, p = 0.29). Maternal consumption of chocolate desserts once daily or more frequently as compared to < 7 times weekly was associated with a 76% reduction in the odds of preeclampsia: adjusted OR = 0.24 (95% CI 0.09-0.63, p = 0.004).
Our study did not confirm the protective association between GBS and preeclampsia that was found in 2 existing state hospital datasets. Chocolate consumption during pregnancy was inversely associated with preeclampsia.
探讨孕妇直肠阴道B族链球菌（GBS）定植与子痫前期结局之间的关联，并确定其他可能与德克萨斯 - 墨西哥边境地区子痫前期相关的因素，如孕妇巧克力摄入量。
2010年4月至2012年4月期间，在德克萨斯州埃尔帕索市一家教学医院对330名分娩妇女进行了病例对照研究。子痫前期病例（n = 165）和无子痫前期的对照（n = 165）按孕周和分娩日期进行匹配。采用条件逻辑回归（对缺失数据进行多重填补）计算经产妇年龄和其他因素调整后的比值比（OR）及95%置信区间（CI）。
病例组（94.6%）和对照组（97.0%）主要为西班牙裔。GBS定植与子痫前期无关：调整后的OR = 1.73（95% CI 0.63 - 4.74，p = 0.29）。与每周食用巧克力甜点少于7次相比，孕妇每天或更频繁食用巧克力甜点与子痫前期发病几率降低76%相关：调整后的OR = 0.24（95% CI 0.09 - 0.63，p = 0.004）。
我们的研究未证实两项现有州立医院数据集中发现的GBS与子痫前期之间的保护性关联。孕期巧克力摄入量与子痫前期呈负相关。
