Department of Obstetrics and Gynecology, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.
Epidemiol Infect. 2013 May;141(5):1089-98. doi: 10.1017/S0950268812001598. Epub 2012 Jul 20.
To determine if there was an association between recto-vaginal group B streptococcus (GBS) colonization and pre-eclampsia, two cross-sectional studies were conducted using statewide hospital databases. The first study analysed data from the state of Florida, USA, and included 190 645 women who were discharged in 2001. This dataset was used to generate the hypothesis that GBS colonization is associated with pre-eclampsia. The second study tested the GBS hypothesis using the records of 577 153 women who delivered in 2004 or 2005 in Texas, USA. Adjusted odds ratios (aOR) for the outcome of pre-eclampsia comparing GBS-positive to GBS-negative women were calculated using logistic regression. The aOR for the association between GBS carriage and pre-eclampsia was 0.71 [95% confidence interval (CI) 0.65-0.77] in the Florida dataset. In the Texas dataset, the overall prevalence of GBS carriage was 14.1% while the overall prevalence of pre-eclampsia was 4.0%. GBS carriers were 31% less likely than non-carriers to have pre-eclampsia (aOR 0.69, 95% CI 0.66-0.72) in Texas. In two large statewide analyses, GBS carriage was inversely associated with pre-eclampsia. A sensitivity analysis revealed that misclassification of GBS status is not a likely explanation of our findings.
为了确定直肠阴道群 B 型链球菌（GBS）定植与子痫前期之间是否存在关联，进行了两项使用全州医院数据库的横断面研究。第一项研究分析了来自美国佛罗里达州的数据集，其中包括 190645 名 2001 年出院的女性。该数据集用于生成 GBS 定植与子痫前期相关的假设。第二项研究使用了美国德克萨斯州 2004 年或 2005 年分娩的 577153 名女性的记录来检验 GBS 假设。使用逻辑回归计算比较 GBS 阳性和 GBS 阴性女性的子痫前期结局的调整比值比（aOR）。在佛罗里达州数据集，GBS 携带与子痫前期之间的关联的 aOR 为 0.71（95%置信区间 0.65-0.77）。在德克萨斯州数据集，GBS 携带的总体流行率为 14.1%，而子痫前期的总体流行率为 4.0%。与非携带者相比，GBS 携带者发生子痫前期的可能性低 31%（aOR 0.69，95%CI 0.66-0.72）。在两项全州范围内的大型分析中，GBS 携带与子痫前期呈负相关。敏感性分析表明，GBS 状态的错误分类不太可能解释我们的发现。
