Huang Yong, Bai Jun Yan, Ren Hong Tao
Bioorg Khim. 2014 May-Jun;40(3):320-6.
piRNAs (piwi-interacting RNA) are a novel class of non-coding small single-stranded RNAs with the length of 26-33 nt. The piRNAs play important biological role through the specific interaction with the piwi proteins of the Argonaute family. piRNA function in embryonic development, maintenance of germline DNA integrity, silencing of transposon transcription, suppressionof translation, formation of heterochromatin, and epigenetic regulation of sex determination. This review summarizes recent research and progress on biogenesis and function of piRNA in eukaryotic species.
piRNA（与Piwi相互作用的RNA）是一类新型的非编码小单链RNA，长度为26 - 33个核苷酸。piRNA通过与Argonaute家族的Piwi蛋白特异性相互作用发挥重要的生物学作用。piRNA在胚胎发育、生殖系DNA完整性的维持、转座子转录的沉默、翻译抑制、异染色质形成以及性别决定的表观遗传调控中发挥作用。本文综述了真核生物中piRNA生物发生和功能的最新研究及进展。
