尿苷二磷酸葡萄糖醛酸基转移酶1A6和1A7的基因多态性与腮腺良性沃辛瘤的风险
Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland.
作者信息
Lacko Martin, Voogd Adri C, van de Goor Rens C E, Roelofs Hennie M J, Te Morsche Rene H M, Bouvy Nicole D, Peters Wilbert H M, Manni Johannes J
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E717-23. doi: 10.1002/hed.24077. Epub 2015 Jul 29.
BACKGROUND
Warthin's tumors of the parotid gland are associated with smoking, whereas pleomorphic adenomas are not. Genetic polymorphisms in biotransformation enzymes, involved in detoxification of toxins and carcinogens in cigarette smoke, might modify the corresponding enzyme activity and influence detoxifying capacity. We hypothesize that these genetic polymorphisms may influence the individual risk for Warthin's tumor, but not for pleomorphic adenomas.
METHODS
Blood from 146 patients with benign parotid gland tumors and 437 controls were investigated for polymorphisms in several biotransformation enzymes. Based on these polymorphisms, patients and controls were divided according to predicted enzyme activity (low, intermediate, and high).
RESULTS
Prevalence of predicted intermediate and high activity UGT1A7 and UGT1A6 genotypes was significantly higher in the patients with Warthin's tumors, but not in patients with pleomorphic adenomas, compared with healthy controls.
CONCLUSION
Predicted intermediate and high activity UGT1A7 and UGT1A6 genotypes are associated with an increased risk for Warthin's tumor. © 2015 Wiley Periodicals, Inc. Head Neck 38: E717-E723, 2016.
背景
腮腺沃辛瘤与吸烟有关，而多形性腺瘤则不然。参与香烟烟雾中毒素和致癌物解毒的生物转化酶的基因多态性可能会改变相应酶的活性并影响解毒能力。我们推测这些基因多态性可能会影响个体患沃辛瘤的风险，但不会影响多形性腺瘤的风险。
方法
对146例腮腺良性肿瘤患者和437例对照者的血液进行了几种生物转化酶基因多态性的研究。根据这些多态性，将患者和对照者按预测的酶活性（低、中、高）进行分组。
结果
与健康对照相比，沃辛瘤患者中预测的UGT1A7和UGT1A6基因中、高活性基因型的患病率显著更高，但多形性腺瘤患者中则不然。
结论
预测的UGT1A7和UGT1A6基因中、高活性基因型与沃辛瘤风险增加有关。©2015威利期刊公司。《头颈》38: E717-E723, 2016。
Zotero 插件