Kotwall C A
Department of Surgery, University of Toronto, St. Michael's Hospital, Ontario, Canada.
Am J Surg. 1992 Dec;164(6):646-7. doi: 10.1016/s0002-9610(05)80725-1.
In order to further examine a preliminary association between smoking and the subsequent development of Warthin's tumor, a case-control study was undertaken between the years 1980 and 1989. Consecutive patients with Warthin's tumor served as cases, and consecutive patients with pleomorphic adenomas served as controls. A positive history of smoking was defined as a patient with greater than a 10-pack year history. There were 28 cases and 69 controls (ratio: 1:2.5). The number of male to female patients with Warthin's tumor and pleomorphic adenoma was 22 to 6 (3.7:1) and 22 to 47 (1:2.1), respectively. The mean age at presentation with Warthin's tumor or pleomorphic adenoma was 60.7 years and 40.7 years, respectively. In those patients for whom a definite smoking history was known (93 patients), an odds ratio of 8.1 (p < 0.001) was calculated. In order to exclude sex as a possible confounder, the odds ratio in males only was 6.4 (p = 0.007). In order to exclude age as a possible confounder, the odds ratio in all patients over 45 years (48 patients) was 11.2 (p < 0.001). In summary, smokers have eight times the risk of developing a Warthin's tumor than nonsmokers. This case-control study suggests that smoking may be one of the etiologic factors associated with this benign salivary gland tumor.
为了进一步研究吸烟与沃辛瘤后续发生之间的初步关联，于1980年至1989年间开展了一项病例对照研究。连续的沃辛瘤患者作为病例组，连续的多形性腺瘤患者作为对照组。吸烟史阳性定义为吸烟量超过10包年的患者。共有28例病例和69例对照（比例为1:2.5）。沃辛瘤患者和多形性腺瘤患者的男女比例分别为22:6（3.7:1）和22:47（1:2.1）。出现沃辛瘤或多形性腺瘤时的平均年龄分别为60.7岁和40.7岁。在已知明确吸烟史的患者（93例）中，计算出的优势比为8.1（p<0.001）。为排除性别作为可能的混杂因素，仅在男性中计算的优势比为6.4（p = 0.007）。为排除年龄作为可能的混杂因素，在所有45岁以上的患者（48例）中计算的优势比为11.2（p<0.001）。总之，吸烟者患沃辛瘤的风险是非吸烟者的八倍。这项病例对照研究表明，吸烟可能是与这种涎腺良性肿瘤相关的病因之一。
