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Arch Biochem Biophys. 2013 Mar;531(1-2):100-9. doi: 10.1016/j.abb.2012.09.008. Epub 2012 Sep 27.
3
Biomimetic delivery with micro- and nanoparticles.仿生递药：微纳米粒子系统
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4
Fast-Scan DSC and its role in pharmaceutical physical form characterisation and selection.快速扫描 DSC 及其在药物物理形态特征分析和选择中的作用。
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5
A new chimeric drug delivery nano system (chi-aDDnS) composed of PAMAM G 3.5 dendrimer and liposomes as doxorubicin's carrier. In vitro pharmacological studies.一种由聚酰胺-胺（PAMAM）G 3.5树枝状大分子和脂质体组成的新型嵌合药物递送纳米系统（chi-aDDnS）作为阿霉素的载体。体外药理学研究。
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6
Differential scanning calorimetry techniques: applications in biology and nanoscience.差示扫描量热法技术：在生物学和纳米科学中的应用
J Biomol Tech. 2010 Dec;21(4):167-93.
7
New chimeric advanced Drug Delivery nano Systems (chi-aDDnSs) as doxorubicin carriers.新型嵌合型高级药物输送纳米系统（chi-aDDnSs）作为多柔比星载体。
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Differential Scanning Calorimetry (DSC): a tool to study the thermal behavior of lipid bilayers and liposomal stability.差示扫描量热法（DSC）：一种研究脂质双层热行为和脂质体稳定性的工具。
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10
Differential scanning calorimetry in life science: thermodynamics, stability, molecular recognition and application in drug design.生命科学中的差示扫描量热法：热力学、稳定性、分子识别及在药物设计中的应用
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生物物理学与热力学：仿生药物递送纳米系统的科学基石。

Biophysics and Thermodynamics: The Scientific Building Blocks of Bio-inspired Drug Delivery Nano Systems.

作者信息

Demetzos Costas

机构信息

Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou 15771, Athens, Greece,

出版信息

AAPS PharmSciTech. 2015 Jun;16(3):491-5. doi: 10.1208/s12249-015-0321-1. Epub 2015 Apr 22.

DOI:10.1208/s12249-015-0321-1
PMID:25899798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4444628/
Abstract

Biophysics and thermodynamics are considered as the scientific milestones for investigating the properties of materials. The relationship between the changes of temperature with the biophysical variables of biomaterials is important in the process of the development of drug delivery systems. Biophysics is a challenge sector of physics and should be used complementary with the biochemistry in order to discover new and promising technological platforms (i.e., drug delivery systems) and to disclose the 'silence functionality' of bio-inspired biological and artificial membranes. Thermal analysis and biophysical approaches in pharmaceuticals present reliable and versatile tools for their characterization and for the successful development of pharmaceutical products. The metastable phases of self-assembled nanostructures such as liposomes should be taken into consideration because they represent the thermal events can affect the functionality of advanced drug delivery nano systems. In conclusion, biophysics and thermodynamics are characterized as the building blocks for design and development of bio-inspired drug delivery systems.

摘要

生物物理学和热力学被视为研究材料特性的科学里程碑。在药物递送系统的开发过程中，温度变化与生物材料的生物物理变量之间的关系至关重要。生物物理学是物理学中一个具有挑战性的领域，应与生物化学互补使用，以发现新的、有前景的技术平台（即药物递送系统），并揭示受生物启发的生物膜和人工膜的“沉默功能”。药物中的热分析和生物物理方法为其表征以及药物产品的成功开发提供了可靠且通用的工具。应考虑自组装纳米结构（如脂质体）的亚稳相，因为它们代表的热事件会影响先进药物递送纳米系统的功能。总之，生物物理学和热力学被视为受生物启发的药物递送系统设计和开发的基石。