智能软模板法合成中空介孔生物活性玻璃微球。
Smart soft-templating synthesis of hollow mesoporous bioactive glass spheres.
机构信息
World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan) http://www.yamauchi-labo.com.
Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555 (Japan).
出版信息
Chemistry. 2015 May 26;21(22):8038-42. doi: 10.1002/chem.201406570. Epub 2015 Apr 20.
Hollow bioactive glass spheres with mesoporous shells were prepared by using dual soft templates, a diblock co-polymer poly(styrene-b-acrylic acid) (PS-b-PAA) and a cationic surfactant cetyltrimethylammonium bromide (CTAB). Hollow mesoporous bioactive glass (HMBG) spheres comprise the large hollow interior with vertical mesochannels in shell, which realize large uptake of drugs and their sustained release. The formation of hydroxyapatite layer on the surface of HMBG particles shows the clear evidence for promising application in bone regeneration.
采用双软模板法，即两亲嵌段共聚物聚（苯乙烯-丙烯酸）（PS-b-PAA）和阳离子表面活性剂十六烷基三甲基溴化铵（CTAB），制备了具有介孔壳的中空生物活性玻璃球。中空介孔生物活性玻璃（HMBG）球由壳内垂直介孔道的大中空内腔组成，实现了药物的大量摄取和持续释放。HMBG 颗粒表面形成羟基磷灰石层，这为其在骨再生中的应用提供了有前景的证据。
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