与胺碘酮治疗相关的急性坏死性肌病

Acute necrotising myopathy associated with amiodarone therapy.

作者信息

Clouston P D, Donnelly P E

机构信息

Repatriation General Hospital, Concord, NSW, Australia.

出版信息

Aust N Z J Med. 1989 Oct;19(5):483-5. doi: 10.1111/j.1445-5994.1989.tb00314.x.

DOI:10.1111/j.1445-5994.1989.tb00314.x

PMID:2590102

Abstract

We report a patient who developed an acute painful proximal myopathy associated with the use of amiodarone. The temporal course, the presence of amiodarone related hypothyroidism and neuropathy, as well as the patient's improvement on drug withdrawal were consistent with a drug reaction. Muscle biopsy demonstrated an acute necrotising myopathy. The mechanism for this reaction is unclear.

摘要

我们报告了一名使用胺碘酮后发生急性疼痛性近端肌病的患者。其时间进程、存在胺碘酮相关的甲状腺功能减退和神经病变，以及患者停药后病情改善，均符合药物反应。肌肉活检显示为急性坏死性肌病。这种反应的机制尚不清楚。