Hirose-Kumagai A, Akamatsu N
Department of Biochemistry, St. Marianna University School of Medicine, Kawasaki, Japan.
Biochem Biophys Res Commun. 1989 Nov 15;164(3):1105-12. doi: 10.1016/0006-291x(89)91783-x.
Partial hepatectomy results in an increase in the ability of the liver cells to bind 125I-labeled transferrin to surface receptors. Scatchard analysis of the binding of transferrin in regenerating rat liver indicates that this increase was due to an increase in the number of transferrin receptors on the cell surface. When we measured total cellular transferrin receptor number, we found that control and regenerating livers had identical amounts of receptor number. The increase in the surface receptor number is apparently due to the translocation of intracellular transferrin receptor to the cell surface.
部分肝切除术后，肝细胞与125I标记的转铁蛋白结合至表面受体的能力增强。对再生大鼠肝脏中转铁蛋白结合情况进行Scatchard分析表明，这种增强是由于细胞表面转铁蛋白受体数量增加所致。当我们测量细胞内转铁蛋白受体总数时，发现对照肝脏和再生肝脏的受体数量相同。表面受体数量的增加显然是由于细胞内转铁蛋白受体转位至细胞表面所致。
