Minakami H, Sotomatsu A, Ohma C, Nakano M
College of Medical Care and Technology, Gunma University, Japan.
Arzneimittelforschung. 1989 Sep;39(9):1090-1.
To evaluate a possible antioxidant activity of probucol on NADPH-dependent microsomal lipid peroxidation and on iron-doxorubicin (adriamycin) complex-induced phospholipid peroxidation, the effects were compared with another powerful antioxidant, 2-OH-estrone. Antioxidant activity of 10 mumol/l probucol in NADPH-dependent microsomal lipid peroxidation corresponded to 4 mumol/l 2-OH-estrone. Together with the results obtained from iron-doxorubicin complex-induced phospholipid peroxidation, it was concluded that probucol is a potent inhibitor of lipid peroxidation and has one-quarter to one-half the antioxidant activity of 2-OH-estrone in vitro.
为评估普罗布考对NADPH依赖的微粒体脂质过氧化作用以及铁-阿霉素复合物诱导的磷脂过氧化作用的潜在抗氧化活性，将其作用与另一种强效抗氧化剂2-羟基雌酮进行了比较。在NADPH依赖的微粒体脂质过氧化作用中，10μmol/L普罗布考的抗氧化活性相当于4μmol/L 2-羟基雌酮。结合铁-阿霉素复合物诱导的磷脂过氧化作用所获得的结果，得出结论：普罗布考是一种有效的脂质过氧化抑制剂，在体外其抗氧化活性为2-羟基雌酮的四分之一至二分之一。
