Amann Valerie C, Maru Neal K, Jain Vivek
George Washington University, Washington, DC.
Department of Dermatology, University Hospital Zurich, Zürich, Switzerland.
J Clin Sleep Med. 2015 Nov 15;11(11):1341-3. doi: 10.5664/jcsm.5204.
Wilson disease (WD) is an autosomal recessive disorder of copper metabolism resulting in copper accumulation in a number of organs including the liver, brain, and cornea, predominantly leading to hepatic, neurologic, and psychiatric manifestations. An association between WD and sleep problems is not commonly recognized, and sleep complaints are often overlooked. Daytime hypersomnolence is even more rarely reported in this population. We report a case of WD and hypersomnolence objectively confirmed by a multiple sleep latency test (MSLT). Consequently, we suggest that increased awareness, assessment, and treatment of sleep disorders, including daytime sleepiness, may help improve patients' quality of life.
威尔逊病（WD）是一种常染色体隐性铜代谢紊乱疾病，会导致铜在包括肝脏、大脑和角膜在内的多个器官中蓄积，主要引发肝脏、神经和精神方面的症状。WD与睡眠问题之间的关联并不常见，睡眠方面的主诉常常被忽视。在这一人群中，白天过度嗜睡的报告更为罕见。我们报告一例经多次睡眠潜伏期试验（MSLT）客观证实的WD伴过度嗜睡病例。因此，我们建议提高对睡眠障碍（包括白天嗜睡）的认识、评估和治疗，这可能有助于改善患者的生活质量。
