Cochen De Cock Valérie, Girardot-Tinant Nadège, Woimant France, Poujois Aurélia
Sleep Unit, Beau Soleil Clinic, 119 Avenue de Lodève, 34070, Montpellier, France.
EuroMov, Montpellier University, 700 Avenue du Pic Saint Loup, 34090, Montpellier, France.
Curr Treat Options Neurol. 2018 Sep 27;20(11):46. doi: 10.1007/s11940-018-0531-4.
The aim of this article was to review the different sleep disorders associated with Wilson's disease (WD), their mechanisms and their treatments.
Some of these disorders such as REM sleep behavior disorder or sleepiness can appear as a prodromal phase phenomenon in WD allowing an early treatment of the disease and sometimes a resolution of the sleep disorder. Sleep disorders in WD are frequent combining insomnia, daytime sleepiness, restless legs syndrome (RLS), cataplexy-like episodes, and REM sleep behavior disorder (RBD). Sleep recordings confirm these disorders. Mechanisms involved in these disorders are complex associating (a) lesions of the pathways regulating sleep and wake or mood but also controlling movement, (b) iatrogenic effects of the treatments, and (3) consequences of the motor or dysautonomic or metabolic disorders.
本文旨在综述与威尔逊病（WD）相关的不同睡眠障碍、其机制及治疗方法。
其中一些障碍，如快速眼动睡眠行为障碍或嗜睡，可作为WD的前驱期现象出现，从而实现疾病的早期治疗，有时还可解决睡眠障碍。WD中的睡眠障碍很常见，包括失眠、日间嗜睡、不宁腿综合征（RLS）、类猝倒发作和快速眼动睡眠行为障碍（RBD）。睡眠记录证实了这些障碍。这些障碍所涉及的机制很复杂，包括（a）调节睡眠和觉醒或情绪但也控制运动的通路受损，（b）治疗的医源性效应，以及（3）运动、自主神经功能障碍或代谢紊乱的后果。
