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当呼吸道病原体侵袭皮肤时:一位肺移植患者的皮肤结核

When a respiratory pathogen turns to the skin: cutaneous tuberculosis in a lung transplant patient.

作者信息

Voigtländer Torsten, Cornberg Markus, Gottlieb Jens, Welte Tobias, Suerbaum Sebastian, Bange Franz-Christoph

机构信息

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str. 1, 30655 Hannover, Germany

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

出版信息

Ther Adv Respir Dis. 2015 Oct;9(5):260-2. doi: 10.1177/1753465815581152. Epub 2015 Apr 22.

DOI:10.1177/1753465815581152
PMID:25902867
Abstract

A 62-year-old male, who received immune suppressive therapy due to a lung transplantation several years ago, developed multiple painful abscesses in the right forearm. First misdiagnosed as staphylococcal abscesses, Mycobacterium tuberculosis was eventually cultured from the abscesses. In addition, the patient also suffered from pulmonary tuberculosis and respiratory specimens were also culture-positive for Mycobacterium tuberculosis. Cutaneous tuberculosis must be kept as a differential diagnosis in the case of abscess-like lesions on the skin, especially in immunocompromised patients. Mycobacteria specific tests (polymerase chain reaction in respiratory samples and wound smears) and antituberculotic combination therapy are necessary to treat Mycobacterium tuberculosis infection/reactivation adequately.

摘要

一名62岁男性,几年前因肺移植接受免疫抑制治疗,右前臂出现多处疼痛性脓肿。最初被误诊为葡萄球菌脓肿,最终从脓肿中培养出结核分枝杆菌。此外,该患者还患有肺结核,呼吸道标本结核分枝杆菌培养也呈阳性。对于皮肤出现脓肿样病变的情况,尤其是免疫功能低下的患者,必须将皮肤结核作为鉴别诊断。为了充分治疗结核分枝杆菌感染/再激活,进行分枝杆菌特异性检测(呼吸道样本和伤口涂片的聚合酶链反应)和抗结核联合治疗是必要的。

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