Recarti C, Sep S J S, Stehouwer C D A, Unger T
CARIM-School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Curr Hypertens Rep. 2015 Jun;17(6):554. doi: 10.1007/s11906-015-0554-0.
Diabetes is a common and rapidly growing disease that affects more than 380 million people worldwide and is an established risk factor for cardiovascular disease with differential effects on women compared to men. While the general population of women, particularly young women, has more favourable cardiovascular risk profiles than men, this protective effect has been shown to be lost or even reversed in diabetic women. Several studies have demonstrated a significant diabetes-associated excess risk of cardiovascular disease in women. Sex-specific differences in risk factors associated with diabetes and their management may be responsible for the relative excess cardiovascular risk in women with diabetes. Diabetic women need intensive treatment in order to optimize management of cardiovascular risk factors. Further studies are needed to elucidate the mechanisms underlying the excess cardiovascular risk in diabetic women in order to tailor prevention and treatment strategies.
糖尿病是一种常见且迅速蔓延的疾病，全球有超过3.8亿人受其影响，它是心血管疾病的既定风险因素，对女性的影响与男性不同。虽然一般女性人群，尤其是年轻女性，心血管风险状况比男性更有利，但这种保护作用在糖尿病女性中已显示丧失甚至逆转。多项研究表明，女性糖尿病患者患心血管疾病的风险显著高于非糖尿病女性。与糖尿病及其管理相关的风险因素存在性别差异，这可能是糖尿病女性心血管风险相对较高的原因。糖尿病女性需要强化治疗，以优化心血管危险因素的管理。需要进一步研究以阐明糖尿病女性心血管风险过高的潜在机制，从而制定预防和治疗策略。
