• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

刺橙素通过增加小眼畸形相关转录因子和酪氨酸酶的表达诱导黑色素生成的作用。

Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.

作者信息

Kim Hyo Jung, Kim Il Soon, Dong Yin, Lee Ik-Soo, Kim Jin Sook, Kim Jong-Sang, Woo Je-Tae, Cha Byung-Yoon

机构信息

Research Institute for Biological Functions, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan.

KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.

出版信息

Int J Mol Sci. 2015 Apr 20;16(4):8772-88. doi: 10.3390/ijms16048772.

DOI:10.3390/ijms16048772
PMID:25903150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4425108/
Abstract

The melanin-inducing properties of cirsimaritin were investigated in murine B16F10 cells. Cirsimaritin is an active flavone with methoxy groups, which is isolated from the branches of Lithocarpus dealbatus. Tyrosinase activity and melanin content in murine B16F10 melanoma cells were increased by cirsimaritin in a dose-dependent manner. Western blot analysis revealed that tyrosinase, tyrosinase-related protein (TRP) 1, TRP2 protein levels were enhanced after treatment with cirsimaritin for 48 h. Cirsimaritin also upregulated the expression of microphthalmia-associated transcription factor (MITF) after 24 h of treatment. Furthermore, cirsimaritin induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) in a dose-dependent manner after treatment for 15 min. The cirsimaritin-mediated increase of tyrosinase activity was significantly attenuated by H89, a cAMP-dependent protein kinase A inhibitor. These findings indicate that cirsimaritin stimulates melanogenesis in B16F10 cells by activation of CREB as well as upregulation of MITF and tyrosinase expression, which was activated by cAMP signaling. Finally, the melanogenic effect of cirsimaritin was confirmed in human epidermal melanocytes. These results support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments.

摘要

在小鼠B16F10细胞中研究了 cirsimaritin 的黑色素诱导特性。Cirsimaritin 是一种具有甲氧基的活性黄酮，从白皮柯的树枝中分离得到。Cirsimaritin 以剂量依赖的方式增加了小鼠B16F10黑色素瘤细胞中的酪氨酸酶活性和黑色素含量。蛋白质免疫印迹分析显示，用cirsimaritin处理48小时后，酪氨酸酶、酪氨酸酶相关蛋白（TRP）1、TRP2的蛋白水平增强。处理24小时后，Cirsimaritin还上调了小眼畸形相关转录因子（MITF）的表达。此外，处理15分钟后，cirsimaritin以剂量依赖的方式诱导环磷酸腺苷（cAMP）反应元件结合蛋白（CREB）的磷酸化。cAMP依赖性蛋白激酶A抑制剂H89显著减弱了cirsimaritin介导的酪氨酸酶活性增加。这些发现表明，cirsimaritin通过激活CREB以及上调由cAMP信号激活的MITF和酪氨酸酶表达来刺激B16F10细胞中的黑色素生成。最后，在人表皮黑素细胞中证实了cirsimaritin的黑色素生成作用。这些结果支持了cirsimaritin在紫外线光保护和染发治疗中的假定应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/86b53fe9c6b3/ijms-16-08772-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/669eb7a6c023/ijms-16-08772-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/d1591e5d98cc/ijms-16-08772-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/097f13fd76c4/ijms-16-08772-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/6464b525d83c/ijms-16-08772-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/09a4fdc90f15/ijms-16-08772-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/bd37f32a610e/ijms-16-08772-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/b6cb296b70f1/ijms-16-08772-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/86b53fe9c6b3/ijms-16-08772-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/669eb7a6c023/ijms-16-08772-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/d1591e5d98cc/ijms-16-08772-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/097f13fd76c4/ijms-16-08772-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/6464b525d83c/ijms-16-08772-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/09a4fdc90f15/ijms-16-08772-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/bd37f32a610e/ijms-16-08772-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/b6cb296b70f1/ijms-16-08772-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e944/4425108/86b53fe9c6b3/ijms-16-08772-g007.jpg

相似文献

1
Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.刺橙素通过增加小眼畸形相关转录因子和酪氨酸酶的表达诱导黑色素生成的作用。
Int J Mol Sci. 2015 Apr 20;16(4):8772-88. doi: 10.3390/ijms16048772.
2
Gynostemma pentaphyllum saponins induce melanogenesis and activate cAMP/PKA and Wnt/β-catenin signaling pathways.绞股蓝总皂苷诱导黑色素生成，并激活 cAMP/PKA 和 Wnt/β-连环蛋白信号通路。
Phytomedicine. 2019 Jul;60:153008. doi: 10.1016/j.phymed.2019.153008. Epub 2019 Jul 1.
3
Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.己烯雌酚通过 cAMP-PKA 介导的上调小鼠 B16 黑素瘤细胞中的酪氨酸酶和 MITF 促进黑素生成。
Steroids. 2011 Nov;76(12):1297-304. doi: 10.1016/j.steroids.2011.06.008. Epub 2011 Jun 30.
4
Fraxinol Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells through CREB/MITF Signaling.水曲柳醇通过 CREB/MITF 信号通路刺激 B16F10 小鼠黑色素瘤细胞中的黑色素生成。
Molecules. 2022 Feb 25;27(5):1549. doi: 10.3390/molecules27051549.
5
Sargaquinoic acid ameliorates hyperpigmentation through cAMP and ERK-mediated downregulation of MITF in α-MSH-stimulated B16F10 cells.Sargaquinoic 酸通过 cAMP 和 ERK 介导的 α-MSH 刺激的 B16F10 细胞中 MITF 的下调来改善色素沉着。
Biomed Pharmacother. 2018 Aug;104:582-589. doi: 10.1016/j.biopha.2018.05.083. Epub 2018 May 25.
6
p44/42 MAPK signaling is a prime target activated by phenylethyl resorcinol in its anti-melanogenic action.苯乙基间苯二酚在其抗黑色素生成作用中通过激活 p44/42 MAPK 信号通路这一主要靶点起作用。
Phytomedicine. 2019 May;58:152877. doi: 10.1016/j.phymed.2019.152877. Epub 2019 Feb 26.
7
Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways.马栗灵通过激活 cAMP/PKA/CREB 和 p38 MAPK/CREB 信号通路发挥其黑色素生成作用。
Oxid Med Cell Longev. 2019 Dec 22;2019:9827519. doi: 10.1155/2019/9827519. eCollection 2019.
8
Unveiling the Potential of Ultrasonic-Assisted Ethanol Extract from in Inhibiting Tyrosinase Activity and Melanin Production in B16F10 Murine Melanocytes.揭示[具体植物或物质名称缺失]的超声辅助乙醇提取物在抑制B16F10小鼠黑素细胞中酪氨酸酶活性和黑色素生成方面的潜力。
Front Biosci (Landmark Ed). 2024 May 20;29(5):194. doi: 10.31083/j.fbl2905194.
9
A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression.一种新型金刚烷基苄基苯甲酰胺衍生物 AP736 通过抑制 cAMP-PKA-CREB 激活的小眼畸形相关转录因子和酪氨酸酶的表达来抑制黑色素生成。
Exp Dermatol. 2013 Nov;22(11):762-4. doi: 10.1111/exd.12248.
10
Scopoletin Stimulates Melanogenesis via cAMP/PKA Pathway and Partially p38 Activation.东莨菪亭通过cAMP/PKA途径及部分p38激活刺激黑色素生成。
Biol Pharm Bull. 2017 Dec 1;40(12):2068-2074. doi: 10.1248/bpb.b16-00690. Epub 2017 Sep 22.

引用本文的文献

1
Carotenoids in red fruit (  Lam.) have a potential role as an anti‑pigmentation agent (Review).红果（学名： ）中的类胡萝卜素作为一种抗色素沉着剂具有潜在作用（综述）。
Biomed Rep. 2024 Feb 1;20(3):54. doi: 10.3892/br.2024.1742. eCollection 2024 Mar.
2
Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS.白皮钻地风醇提物对去卵巢/半乳糖诱导的雌性大鼠记忆损伤的神经保护作用及其代谢物指纹图谱与 UPLC/MS 的关系
Inflammopharmacology. 2024 Apr;32(2):1091-1112. doi: 10.1007/s10787-023-01418-3. Epub 2024 Jan 31.
3

本文引用的文献

1
Soybean-derived glyceollins induce apoptosis through ROS generation.大豆衍生的glyceollins 通过产生 ROS 诱导细胞凋亡。
Food Funct. 2014 Apr;5(4):688-95. doi: 10.1039/c3fo60379b.
2
Diverse immune functions of hemocyanins.血蓝蛋白的多种免疫功能。
Dev Comp Immunol. 2014 Jul;45(1):43-55. doi: 10.1016/j.dci.2014.01.021. Epub 2014 Jan 31.
3
Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation.肝 X 受体激活通过加速 ERK 介导的 MITF 降解来抑制黑色素生成。
DDX3 Upregulates Hydrogen Peroxide-Induced Melanogenesis in Sk-Mel-2 Human Melanoma Cells.
DDX3 上调人黑色素瘤 Sk-Mel-2 细胞中过氧化氢诱导的黑色素生成。
Molecules. 2022 Oct 18;27(20):7010. doi: 10.3390/molecules27207010.
4
Discovery of Pinostrobin as a Melanogenic Agent in cAMP/PKA and p38 MAPK Signaling Pathway.发现 Pinostrobin 是 cAMP/PKA 和 p38 MAPK 信号通路中的黑色素生成剂。
Nutrients. 2022 Sep 9;14(18):3713. doi: 10.3390/nu14183713.
5
The Current State of Knowledge in Biological Properties of Cirsimaritin.刺蒺藜苷生物学特性的研究现状
Antioxidants (Basel). 2022 Sep 19;11(9):1842. doi: 10.3390/antiox11091842.
6
The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds.植物提取物和分离的植物化合物处理对 B16 细胞黑色素生成的调节。
Molecules. 2022 Jul 7;27(14):4360. doi: 10.3390/molecules27144360.
7
Genus: Phytochemistry and Biological Activities Update.属：植物化学与生物活性更新。
Molecules. 2021 May 6;26(9):2733. doi: 10.3390/molecules26092733.
8
Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways.甘草苷和甘草素通过增强p38和PKA信号通路诱导黑色素生成。
Medicines (Basel). 2019 Jun 22;6(2):68. doi: 10.3390/medicines6020068.
9
Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation.Pratol，一种 O-甲基化黄酮，通过上调 p-p38 和 p-JNK 诱导 B16F10 黑素瘤细胞中的黑色素生成。
Molecules. 2017 Oct 11;22(10):1704. doi: 10.3390/molecules22101704.
10
Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes.戈米辛N通过调节黑素细胞中的PI3K/Akt和MAPK/ERK信号通路来抑制黑色素生成。
Int J Mol Sci. 2017 Feb 22;18(2):471. doi: 10.3390/ijms18020471.
J Invest Dermatol. 2013 Apr;133(4):1063-71. doi: 10.1038/jid.2012.409. Epub 2012 Dec 6.
4
Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells.4'-O-甲基化黄酮类化合物对 B16F10 黑素瘤细胞中黑色素生成的诱导作用。
J Nat Med. 2013 Oct;67(4):705-10. doi: 10.1007/s11418-012-0727-y. Epub 2012 Dec 4.
5
Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: a structure-activity relationship study.来自 Tecurium ramosissimum 的类黄酮和倍半萜促进人癌细胞的增殖抑制和增强抗氧化活性：构效关系研究。
Environ Toxicol Pharmacol. 2011 Nov;32(3):336-48. doi: 10.1016/j.etap.2011.07.003. Epub 2011 Jul 12.
6
Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance.白花蒿素类化合物可调节细菌的耐药性。
Molecules. 2011 Jun 10;16(6):4828-35. doi: 10.3390/molecules16064828.
7
Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells.活性氧介导的内质网应激和线粒体功能障碍导致芹菜素诱导人胆囊癌细胞 GBC-SD 细胞凋亡。
Cancer Lett. 2010 Sep 28;295(2):252-9. doi: 10.1016/j.canlet.2010.03.008. Epub 2010 Mar 31.
8
Cardamonin suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling.小豆蔻明通过抑制Wnt/β-连环蛋白信号通路来抑制黑色素生成。
Biochem Biophys Res Commun. 2009 Dec 18;390(3):500-5. doi: 10.1016/j.bbrc.2009.09.124. Epub 2009 Oct 1.
9
2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG) induces melanogenesis in B16 cells by MAP kinase activation and tyrosinase upregulation.2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷（THSG）通过丝裂原活化蛋白激酶激活和酪氨酸酶上调诱导B16细胞中的黑色素生成。
Life Sci. 2009 Aug 26;85(9-10):345-50. doi: 10.1016/j.lfs.2009.05.022. Epub 2009 Jun 13.
10
Partially purified Curcuma longa inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signalling in B16F10 cells.部分纯化的姜黄通过细胞外信号调节激酶或Akt激活介导的信号通路抑制α-黑素细胞刺激素刺激的B16F10细胞黑素生成。
Exp Dermatol. 2009 Aug;18(8):689-94. doi: 10.1111/j.1600-0625.2009.00857.x. Epub 2009 Mar 7.