Department of Computer Science in Economics, University of Lodz, 90-214 Lodz, Poland.
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland.
Molecules. 2022 Jul 7;27(14):4360. doi: 10.3390/molecules27144360.
Plants are a rich source of secondary metabolites that exhibit numerous desired properties. The compounds may influence the biology of melanocytes, pigment cells that produce melanin, by modulating numerous signaling pathways, including cAMP/PKA, MAPKs and PI3K/AKT. Its downstream target is microphthalmia-associated transcription factor, responsible for the expression of the tyrosinase enzyme, which plays a major role in melanogenesis. Therefore, this literature review aims to provide insights related to melanogenesis modulation mechanisms of plant extracts and isolated plant compounds in B16 cells. Database searches were conducted using online-based library search instruments from 2012 to 2022, such as NCBI-PubMed and Google Scholar. Upregulation or downregulation of signaling pathways by phytochemicals can influence skin hypo- and hyperpigmentation by changing the level of melanin production, which may pose a significant cosmetic issue. Therefore, plant extracts or isolated plant compounds may be used in the therapy of pigmentation disorders.
植物是次生代谢产物的丰富来源，具有许多所需的特性。这些化合物可以通过调节包括 cAMP/PKA、MAPK 和 PI3K/AKT 在内的多种信号通路来影响产生黑色素的色素细胞黑素细胞的生物学。其下游靶标是小眼畸形相关转录因子，负责酪氨酸酶酶的表达，酪氨酸酶在黑色素生成中起主要作用。因此，本文综述旨在提供与植物提取物和分离的植物化合物在 B16 细胞中对黑色素生成调节机制相关的见解。数据库搜索使用了 2012 年至 2022 年在线图书馆搜索工具，如 NCBI-PubMed 和 Google Scholar。植物化学物质对信号通路的上调或下调可以通过改变黑色素产生的水平来影响皮肤的色素减退和色素沉着过度，这可能是一个重大的美容问题。因此，植物提取物或分离的植物化合物可能用于色素沉着障碍的治疗。
