白细胞介素7受体α链（IL-7Ra）中的基因变异与中欧斯洛伐克人群的多发性硬化症风险及残疾进展相关。
Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population.
作者信息
Čierny Daniel, Hányšová Sandra, Michalik Jozef, Kantorová Ema, Kurča Egon, Škereňová Mária, Lehotský Ján
机构信息
Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic.
Department of Neurology, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic.
出版信息
J Neuroimmunol. 2015 May 15;282:80-4. doi: 10.1016/j.jneuroim.2015.03.010. Epub 2015 Mar 18.
In this study, we determined the association between rs6897932 in interleukin 7 receptor α (IL7Ra) gene and the risk and disability progression of multiple sclerosis (MS) in 270 MS patients and 303 controls. We found allele C to be associated with the risk of MS and minor allele T to be protective against MS development. Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores. The minor allele T and genotype TT are protective against a rapid disability progression in MS in the Central European Slovak population.
在本研究中，我们在270例多发性硬化症（MS）患者和303例对照中确定了白细胞介素7受体α（IL7Ra）基因中的rs6897932与MS风险及残疾进展之间的关联。我们发现等位基因C与MS风险相关，而次要等位基因T对MS发展具有保护作用。此外，我们首次揭示，通过MSSS评分评估，IL7Ra基因中的rs6897932与MS进展相关。在中欧斯洛伐克人群中，次要等位基因T和基因型TT对MS患者快速残疾进展具有保护作用。
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