Benešová Yvonne, Vašků Anna, Bienertová-Vašků Julie
Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00, Brno, Czech Republic.
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Acta Neurol Belg. 2018 Sep;118(3):493-501. doi: 10.1007/s13760-018-0994-9. Epub 2018 Aug 1.
Pro-inflammatory and anti-inflammatory cytokines have been shown to play a crucial role in the pathophysiology of multiple sclerosis (MS). We investigated the association between interleukin (IL) IL6-174 G/C (rs1800795), IL7RA C/T (rs6897932), and IL-12B A1188C (rs3212227) gene polymorphisms (SNPs) and MS. The study consisted of 297 unrelated MS patients and 135 healthy individuals. In IL6-174G/C (rs1800795), a significant association between the C allele and MS risk [OR 1.41, 95% CI (1.05-1.92); P = 0.025] was found. Carriage of genotypes CC and CG were more common in MS patients [OR 1.58, 95% CI (1.04-2.39); P = 0.031] and also in female MS patients [OR 1.68, 95% CI (1.02-2.79); P = 0.043]. However, after applying Bonferroni's correction the differences did not remain significant. No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed. Regarding IL-12B A1188C (rs3212227), a significant association between the CC genotype and MS progression, expressed as MSSS, was demonstrated in the female MS group. Our results indicate that the distribution of IL6-174G/C (rs1800795) SNP was marginally associated with MS susceptibility. We also showed that IL-12B A1188C (rs3212227) can contribute to the progression of the disease in the Czech population.
促炎和抗炎细胞因子已被证明在多发性硬化症（MS）的病理生理学中起关键作用。我们研究了白细胞介素（IL）IL6 - 174 G/C（rs1800795）、IL7RA C/T（rs6897932）和IL - 12B A1188C（rs3212227）基因多态性（SNP）与MS之间的关联。该研究包括297名无亲缘关系的MS患者和135名健康个体。在IL6 - 174G/C（rs1800795）中，发现C等位基因与MS风险之间存在显著关联[比值比（OR）1.41，95%置信区间（CI）（1.05 - 1.92）；P = 0.025]。基因型CC和CG在MS患者中更常见[OR 1.58，95% CI（1.04 - 2.39）；P = 0.031]，在女性MS患者中也是如此[OR 1.68，95% CI（1.02 - 2.79）；P = 0.043]。然而，应用Bonferroni校正后，差异不再显著。未观察到IL7RA C/T（rs6897932）和IL12B A1188C（rs3212227）基因多态性与MS易感性之间存在显著关联。关于IL - 12B A1188C（rs3212227），在女性MS组中，CC基因型与以多发性硬化症严重程度评分（MSSS）表示的MS进展之间存在显著关联。我们的结果表明，IL6 - 174G/C（rs1800795）SNP的分布与MS易感性存在微弱关联。我们还表明，在捷克人群中，IL - 12B A1188C（rs3212227）可能与疾病进展有关。
