Poyser N L, Walker F M
Ciba Found Symp. 1978(64):261-92. doi: 10.1002/9780470720479.ch12.
In several mammalian species, prostaglandin F2 alpha (PGF2 alpha) released from the uterus causes corpus luteum regression, and thereby regulates the length of the oestrous cycle or pseudopregnancy. If the animal becomes pregnant, luteal regression must be prevented since ovarian progesterone is necessary for pregnancy maintenance during at least the first one-third of pregnancy. Evidence is presented that the guinea-pig conceptus produces an antiluteolytic factor which suppresses PGF2 alpha output from the uterus by preventing the increase in uterine PGF2 alpha-synthesizing capacity which occurs around the time of luteolysis. Experiments in unilaterally pregnant guinea-pigs, with either an intact or a transected sterile horn, indicate that this factor acts both locally systemically, though separation of the two uterine horns does greatly reduce its effect on the sterile side. Oestradiol administered during early pregnancy induces abortion, which is associated with a high PGF2 alpha-synthesizing capacity of the uterus. However, luteal regression does not take place while the conceptuses are in the uterus. Spontaneously aborting guinea-pigs behave similarly. The conceptus may therefore secrete a luteotrophic hormone as well. Luteal maintenance during early pregnancy in other species is discussed, since experiments on sheep indicate that the sheep embryo may also secrete an antiluteolytic factor.
在几种哺乳动物中，子宫释放的前列腺素F2α（PGF2α）会导致黄体退化，从而调节发情周期或假孕的时长。如果动物怀孕，黄体退化必须被阻止，因为至少在怀孕的前三分之一时间里，卵巢孕酮对维持妊娠是必需的。有证据表明，豚鼠的孕体产生一种抗黄体溶解因子，该因子通过阻止在黄体溶解时子宫PGF2α合成能力的增加来抑制子宫PGF2α的分泌。在单侧怀孕的豚鼠身上进行的实验，一侧子宫完整，另一侧子宫横断且无菌，结果表明该因子既能局部起作用，也能全身起作用，不过将两个子宫角分开会大大降低其对无菌侧的作用。怀孕早期给予雌二醇会导致流产，这与子宫高PGF2α合成能力有关。然而，当孕体在子宫内时，黄体不会退化。自然流产的豚鼠也有类似表现。因此，孕体可能也会分泌一种促黄体激素。文中还讨论了其他物种怀孕早期的黄体维持情况，因为对绵羊的实验表明，绵羊胚胎可能也会分泌一种抗黄体溶解因子。
