Vilela Manuel A P, Sbruzzi Graciele, Pellanda Lucia C
1Ophthalmology Department,Universidade Federal de Pelotas,Pelotas,RS,Brazil.
2School of Physical Education,Universidade Federal do Rio Grande do Sul,Porto Alegre,RS,Brazil.
Cardiol Young. 2016 Mar;26(3):477-84. doi: 10.1017/S104795111500044X. Epub 2015 Apr 23.
CHDs form a complex and heterogeneous group of clinical entities, with high morbidity and mortality. With the advancement of surgical and invasive techniques and clinical treatment, the survival of these patients has increased significantly, and there are reports of a high prevalence of ocular abnormalities in this group. The objective of this study was to estimate the prevalence of ocular findings in children and adolescents diagnosed with CHD.
A systematic search was conducted in the following databases: MEDLINE (via PubMed), EMBASE, and Cochrane CENTRAL, in addition to a manual search on studies published on the patient, from inception until August, 2014. Observational studies assessing the prevalence of ocular abnormalities in children and adolescents with CHDs were included.
Of the 2413 articles identified, eight were included, comprising a total of 1061 patients. Among them, the lowest and highest prevalences observed were 6.3 and 65%, respectively. The weighted average prevalence of ocular abnormalities was 32.5% (CI95% 19.3-49.3). Strabismus, cataracts, and retinopathy were the most frequently observed alterations.
The prevalence of ocular abnormalities in children and adolescents with CHDs was 32.5%, demonstrating that ocular consequences are not uncommon in this population and may have relevant clinical impact. These results reinforce the need for ophthalmological evaluation of patients with CHDs.
先天性心脏病（CHD）构成了一组复杂且异质性的临床病症，具有高发病率和高死亡率。随着外科手术、介入技术及临床治疗的进步，这些患者的生存率显著提高，且有报道称该群体中眼部异常的患病率较高。本研究的目的是评估被诊断为CHD的儿童和青少年中眼部检查结果的患病率。
除了对自研究起始至2014年8月发表的关于患者的研究进行手工检索外，还在以下数据库中进行了系统检索：MEDLINE（通过PubMed）、EMBASE和Cochrane CENTRAL。纳入评估CHD患儿和青少年眼部异常患病率的观察性研究。
在检索到的2413篇文章中，纳入了8篇，共涉及1061例患者。其中，观察到的最低和最高患病率分别为6.3%和65%。眼部异常的加权平均患病率为32.5%（95%CI 19.3 - 49.3）。斜视、白内障和视网膜病变是最常观察到的病变。
CHD患儿和青少年中眼部异常的患病率为32.5%，表明在该人群中眼部问题并不罕见，且可能具有相关临床影响。这些结果强化了对CHD患者进行眼科评估的必要性。
