Sawamura Masanori, Toma Keiichiro, Unai Yuki, Sekiya Tomoko, Nishinaka Kazuhito, Udaka Fukashi
Department of Neurology, Sumitomo Hospital.
Rinsho Shinkeigaku. 2015;55(4):266-8. doi: 10.5692/clinicalneurol.55.266.
A 62-year-old woman experienced uncomfortable genial sensation in 2010. Her uncomfortable sensation was exacerbated during rest at night and improved by walking. She exhibited short-stepped gait with postural disturbance and was diagnosed as suffering from Parkinson's disease (PD) in 2013. Administration of clonazepam and pramipexisole improved her uncomfortable genial sensation. In persistent genital arousal disorder (PGAD)/restless genial syndrome (RGS), abnormal genital sensation occurred without sexual desire, which was relieved by clonazepam administration. PGAD/RGS often coexists with restless legs syndrome (RLS). PGAD/RGS and RLS share common characteristics. This is the first case report of PD following PGAD/RGS, suggesting similar underlying mechanisms between PGAD/RGS and RLS associated with PD.
一名62岁女性在2010年出现会阴部不适感觉。她的不适感觉在夜间休息时加剧，行走后改善。她表现出短步幅步态伴姿势障碍，2013年被诊断为患有帕金森病（PD）。服用氯硝西泮和普拉克索改善了她的会阴部不适感觉。在持续性性唤起障碍（PGAD）/会阴部不安综合征（RGS）中，无性欲情况下出现异常会阴部感觉，服用氯硝西泮可缓解。PGAD/RGS常与不安腿综合征（RLS）共存。PGAD/RGS和RLS有共同特征。这是PGAD/RGS后发生PD的首例病例报告，提示PGAD/RGS与伴有PD的RLS之间存在相似的潜在机制。
