Köksal Hande, Kurban Sevil, Doğru Osman
Department of General Surgery, Konya Training and Research Hospital, Konya, Turkey.
Department of Biochemistry, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey.
Ulus Travma Acil Cerrahi Derg. 2015 Mar;21(2):139-42. doi: 10.5505/tjtes.2015.03285.
The aim of this study was to investigate the levels of oxidative stress including total oxidant status, total antioxidant status, and paraoxonase activity in patients with a diagnosis of acute appendicitis.
Seventy-three patients who underwent surgery with a preoperative diagnosis of acute appendicitis (Group I) were included into the study. The control group (Group II) consisted of thirty otherwise healthy subjects. After histopathologic examination, the patients were categorized as follows: 1) Acute focal appendicitis, 2) Acute advanced appendicitis including acute suppurative, phlegmonous and gangrenous appendicitis, 3) Acute perforated appendicitis, 4) Sub-acute appendicitis, and 5) Negative exploration. Blood samples for paraoxonase activities, and total oxidant and antioxidant status levels were obtained preoperatively.
Total oxidant and antioxidant status of the patients in the acute appendicitis group were higher than those of the control group. When paraoxonase activities of Group I was compared with Group II, no significant difference was determined. Both total oxidant and antioxidant status levels of acute perforated appendicitis were higher than those of both acute focal appendicitis and acute advanced appendicitis.
The increase in the oxidative status (total oxidant and antioxidant status) was related with the progression of inflammation to the perforation in acute appendicitis.
本研究旨在调查诊断为急性阑尾炎患者的氧化应激水平，包括总氧化剂状态、总抗氧化剂状态和对氧磷酶活性。
本研究纳入73例术前诊断为急性阑尾炎并接受手术的患者（I组）。对照组（II组）由30名其他方面健康的受试者组成。经过组织病理学检查后，将患者分类如下：1）急性局限性阑尾炎，2）急性进展性阑尾炎，包括急性化脓性、蜂窝织炎性和坏疽性阑尾炎，3）急性穿孔性阑尾炎，4）亚急性阑尾炎，5）阴性探查。术前采集血样检测对氧磷酶活性以及总氧化剂和抗氧化剂状态水平。
急性阑尾炎组患者的总氧化剂和抗氧化剂状态高于对照组。比较I组和II组的对氧磷酶活性，未发现显著差异。急性穿孔性阑尾炎的总氧化剂和抗氧化剂状态水平均高于急性局限性阑尾炎和急性进展性阑尾炎。
氧化状态（总氧化剂和抗氧化剂状态）的增加与急性阑尾炎炎症进展至穿孔有关。
