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用于生物复合骨水泥的磷酸钙骨水泥和聚甲基丙烯酸甲酯的制备。

Preparation of calcium phosphate cement and polymethyl methacrylate for biological composite bone cements.

作者信息

Yang Jun, Zhang Kairui, Zhang Sheng, Fan Jiping, Guo Xinhui, Dong Weiqiang, Wang Shengnan, Chen Yirong, Yu Bin

机构信息

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).

Department of Orthopaedics, 421 hospital of PLA, Guangzhou, Guangdong, China (mainland).

出版信息

Med Sci Monit. 2015 Apr 23;21:1162-72. doi: 10.12659/MSM.893845.

DOI:10.12659/MSM.893845
PMID:25904398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4418284/
Abstract

BACKGROUND

We studied the biological safety, biomechanics, and tissue compatibility of calcium phosphate cement and Polymethyl Methacrylate composite bone cement mixed in different ratios.

MATERIAL/METHODS: CPC and PMMA were mixed in different ratios (3:1, 2:1, 1:1, 1:2, 1:5, 1:10, 1:15, and 1:20). PMMA solvent is a general solvent containing a dissolved preparation of the composite bone cement specific to a given specimen to determine biological safety, biomechanics, and tissue compatibility.

RESULTS

The CPC/PMMA (33%) group, CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group were more in line with the composite bone cement without cytotoxicity requirements. The compressive strength of the CPC/PMMA (67%) group and CPC/PMMA (75%) group was 20 Mpa-30 Mpa, while that of the CPC/PMMA (4.8%) group, CPC/PMMA (6.25%) group, CPC/PMMA (9.1%) group, CPC/PMMA (16.7%) group, CPC/PMMA (33%) group, and CPC/PMMA (50%) group was 40 Mpa-70 Mpa. Curing time was longer in the CPC group (more than 11 min) and shorter in the PMMA group (less than 2 min). The results of weight loss rate showed that there were no significant differences between the CPC/PMMA group (4.8%, 6.25%, 9.1%, 16.7%, 33%) and PMMA control group (p>0.05). With the decrease of CPC content, the rate of weight loss gradually decreased.

CONCLUSIONS

The CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group provide greater variability and selectivity for the composite bone cement in obtaining better application.

摘要

背景

我们研究了不同比例混合的磷酸钙骨水泥和聚甲基丙烯酸甲酯复合骨水泥的生物安全性、生物力学性能及组织相容性。

材料/方法：将磷酸钙骨水泥（CPC）和聚甲基丙烯酸甲酯（PMMA）按不同比例（3:1、2:1、1:1、1:2、1:5、1:10、1:15和1:20）混合。PMMA溶剂是一种通用溶剂，含有针对给定标本的复合骨水泥溶解制剂，以确定生物安全性、生物力学性能及组织相容性。

结果

CPC/PMMA（33%）组、CPC/PMMA（50%）组、CPC/PMMA（67%）组和CPC/PMMA（75%）组更符合无细胞毒性要求的复合骨水泥。CPC/PMMA（67%）组和CPC/PMMA（75%）组的抗压强度为20兆帕至30兆帕，而CPC/PMMA（4.8%）组、CPC/PMMA（6.25%）组、CPC/PMMA（9.1%）组、CPC/PMMA（16.7%）组、CPC/PMMA（33%）组和CPC/PMMA（50%）组的抗压强度为40兆帕至70兆帕。CPC组的固化时间较长（超过11分钟），PMMA组的固化时间较短（少于2分钟）。失重率结果显示，CPC/PMMA组（4.8%、6.25%、9.1%、16.7%、33%）与PMMA对照组之间无显著差异（p>0.05）。随着CPC含量的降低，失重率逐渐下降。

结论

CPC/PMMA（50%）组、CPC/PMMA（67%）组和CPC/PMMA（75%）组为复合骨水泥在获得更好应用方面提供了更大的可变性和选择性。

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