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爆炸测试问题与创伤性脑损伤:导致错误结论的实验模型

Blast Testing Issues and TBI: Experimental Models That Lead to Wrong Conclusions.

作者信息

Needham Charles E, Ritzel David, Rule Gregory T, Wiri Suthee, Young Leanne

机构信息

Southwest Division, Applied Research Associates, Inc. , Albuquerque, NM , USA.

Dyn-FX Consulting Ltd. , Amherstburg, ON , Canada.

出版信息

Front Neurol. 2015 Apr 8;6:72. doi: 10.3389/fneur.2015.00072. eCollection 2015.

Abstract

Over the past several years, we have noticed an increase in the number of blast injury studies published in peer-reviewed biomedical journals that have utilized improperly conceived experiments. Data from these studies will lead to false conclusions and more confusion than advancement in the understanding of blast injury, particularly blast neurotrauma. Computational methods to properly characterize the blast environment have been available for decades. These methods, combined with a basic understanding of blast wave phenomena, enable researchers to extract useful information from well-documented experiments. This basic understanding must include the differences and interrelationships of static pressure, dynamic pressure, reflected pressure, and total or stagnation pressure in transient shockwave flows, how they relate to loading of objects, and how they are properly measured. However, it is critical that the research community effectively overcomes the confusion that has been compounded by a misunderstanding of the differences between the loading produced by a free field explosive blast and loading produced by a conventional shock tube. The principles of blast scaling have been well established for decades and when properly applied will do much to repair these problems. This paper provides guidance regarding proper experimental methods and offers insights into the implications of improperly designed and executed tests. Through application of computational methods, useful data can be extracted from well-documented historical tests, and future work can be conducted in a way to maximize the effectiveness and use of valuable biological test data.

摘要

在过去几年中,我们注意到在同行评审的生物医学期刊上发表的爆炸伤研究数量有所增加,而这些研究采用的实验设计存在缺陷。这些研究的数据将导致错误的结论,并且相比于增进对爆炸伤(尤其是爆炸性神经创伤)的理解,会造成更多的混乱。几十年来,一直存在用于正确表征爆炸环境的计算方法。这些方法与对爆炸波现象的基本理解相结合,使研究人员能够从记录完备的实验中提取有用信息。这种基本理解必须包括瞬态冲击波流中静压、动压、反射压力以及总压或滞止压力的差异和相互关系,它们如何与物体的载荷相关,以及如何进行正确测量。然而,至关重要的是,研究界要有效克服因对自由场炸药爆炸产生的载荷与传统激波管产生的载荷之间差异的误解而加剧的混乱。爆炸比例定律的原理已经确立了几十年,正确应用将大大有助于解决这些问题。本文提供了关于正确实验方法的指导,并深入探讨了设计和执行不当的测试所带来的影响。通过应用计算方法,可以从记录完备的历史测试中提取有用数据,并且未来的工作可以以一种最大化宝贵生物测试数据的有效性和用途的方式进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a5/4389725/316c8d04ec9b/fneur-06-00072-g001.jpg

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