Gomez-Nicola Diego, Boche Delphine
Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD UK.
Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD UK.
Alzheimers Res Ther. 2015 Apr 22;7(1):42. doi: 10.1186/s13195-015-0126-1. eCollection 2015.
Since the genome-wide association studies in Alzheimer's disease have highlighted inflammation as a driver of the disease rather than a consequence of the ongoing neurodegeneration, numerous studies have been performed to identify specific immune profiles associated with healthy, ageing, or diseased brain. However, these studies have been performed mainly in in vitro or animal models, which recapitulate only some aspects of the pathophysiology of human Alzheimer's disease. In this review, we discuss the availability of human post-mortem tissue through brain banks, the limitations associated with its use, the technical tools available, and the neuroimmune aspects to explore in order to validate in the human brain the experimental observations arising from animal models.
由于全基因组关联研究表明，炎症是阿尔茨海默病的驱动因素而非进行性神经退行性变的结果，因此人们开展了大量研究以确定与健康、衰老或患病大脑相关的特定免疫特征。然而，这些研究主要是在体外或动物模型中进行的，而这些模型仅概括了人类阿尔茨海默病病理生理学的某些方面。在这篇综述中，我们讨论了通过脑库获取人类尸检组织的情况、使用该组织的相关局限性、可用的技术工具以及为了在人类大脑中验证动物模型得出的实验观察结果而需要探索的神经免疫方面。
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