基因长度在神经元中很重要。
Gene length matters in neurons.
作者信息
Zylka Mark J, Simon Jeremy M, Philpot Benjamin D
机构信息
Department of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7545, USA.
Department of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7545, USA.
出版信息
Neuron. 2015 Apr 22;86(2):353-5. doi: 10.1016/j.neuron.2015.03.059.
Abstract
A recent study by Gabel et al. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders.
摘要
加贝尔等人（2015年）最近的一项研究发现，雷特综合征中发生突变的基因Mecp2通过与DNA中的甲基化CA位点结合，抑制与神经元生理和连接性相关的长基因（>100 kb）。这项研究为越来越多的涉及神经发育和神经退行性疾病中基因长度和转录机制的文献增添了内容。
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