通过局部和远距离通讯实现神经胶质细胞对神经元连接组的调控
Glial Regulation of the Neuronal Connectome through Local and Long-Distant Communication.
作者信息
Fields R Douglas, Woo Dong Ho, Basser Peter J
机构信息
Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
出版信息
Neuron. 2015 Apr 22;86(2):374-86. doi: 10.1016/j.neuron.2015.01.014.
If "the connectome" represents a complete map of anatomical and functional connectivity in the brain, it should also include glia. Glia define and regulate both the brain's anatomical and functional connectivity over a broad range of length scales, spanning the whole brain to subcellular domains of synaptic interactions. This Perspective article examines glial interactions with the neuronal connectome (including long-range networks, local circuits, and individual synaptic connections) and highlights opportunities for future research. Our understanding of the structure and function of the neuronal connectome would be incomplete without an understanding of how all types of glia contribute to neuronal connectivity and function, from single synapses to circuits.
如果“连接组”代表大脑中解剖学和功能连接的完整图谱，那么它也应该包括神经胶质细胞。神经胶质细胞在广泛的长度尺度上定义和调节大脑的解剖学和功能连接，范围从整个大脑到突触相互作用的亚细胞区域。这篇观点文章探讨了神经胶质细胞与神经元连接组（包括长程网络、局部回路和单个突触连接）的相互作用，并突出了未来研究的机会。如果不了解所有类型的神经胶质细胞如何从单个突触到回路对神经元连接和功能做出贡献，我们对神经元连接组的结构和功能的理解将是不完整的。
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