Chou Chien-Chen, Shih Yang-Hsin, Yen Der-Jen, Kwan Shang-Yeong, Yu Hsiang-Yu
Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Department of Neurology, School of Medicine, National Yang-Ming University.
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Department of Neurosurgery, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Epileptic Disord. 2015 Jun;17(2):177-83. doi: 10.1684/epd.2015.0744.
Epilepsy surgery is beneficial to patients suffering from drug-resistant temporal lobe epilepsy in the short term, but fewer reports of long-term outcomes have been published. To clarify the long-term outcomes of seizure control and health-related quality of life after epilepsy surgery, we enrolled 48 patients suffering from drug-resistant temporal lobe epilepsy. All of the patients received comprehensive presurgical evaluations, including the Quality of Life in Epilepsy Inventory-89 (QOLIE-89) questionnaire to measure their health-related quality of life. Among the patients, 28 patients received surgery (surgical group) and 20 patients remained under medication (medical group). Eight years later, the seizure frequency and QOLIE-89 were evaluated. The seizure-free rate was much higher in the surgical group (53.6%) than in the medical group (5%), eight years after the initial evaluation. The follow-up QOLIE-89 score was significantly higher in the surgical group than in the medical group. Moreover, the seizure frequency inversely correlated to the QOLIE-89 score, regardless of the treatment group. Our results provide evidence that epilepsy surgery confers benefits with respect to seizure control and health-related quality of life for drug-resistant temporal lobe epilepsy patients based on long-term follow-up.
癫痫手术在短期内对耐药性颞叶癫痫患者有益，但关于长期疗效的报道较少。为了阐明癫痫手术后癫痫控制的长期疗效以及与健康相关的生活质量，我们招募了48例耐药性颞叶癫痫患者。所有患者均接受了全面的术前评估，包括使用癫痫患者生活质量量表-89（QOLIE-89）问卷来衡量他们与健康相关的生活质量。其中，28例患者接受了手术（手术组），20例患者继续接受药物治疗（药物组）。八年后，评估癫痫发作频率和QOLIE-89。初次评估八年后，手术组的无癫痫发作率（53.6%）远高于药物组（5%）。手术组的随访QOLIE-89评分显著高于药物组。此外，无论治疗组如何，癫痫发作频率与QOLIE-89评分呈负相关。我们的结果表明，基于长期随访，癫痫手术在癫痫控制和与健康相关的生活质量方面给耐药性颞叶癫痫患者带来了益处。
