Sabatier Manning J, English Arthur W
1Departments of Rehabilitation Medicine and 2Cell Biology, Emory University School of Medicine, Atlanta, GA.
Exerc Sport Sci Rev. 2015 Jul;43(3):163-71. doi: 10.1249/JES.0000000000000047.
This article outlines the novel hypothesis that exercise promotes axon regeneration after peripheral nerve injury through neuronal brain-derived neurotrophic factor (BDNF), and there are three required means of promoting BDNF expression: 1) increased signaling through androgen receptors, 2) increased cAMP-responsive element-binding protein expression, and 3) increased expression of the transcription factor SRY-box containing gene 11.
本文概述了一个新的假说,即运动通过神经元脑源性神经营养因子(BDNF)促进周围神经损伤后轴突再生,并且存在三种促进BDNF表达的必要方式:1)通过雄激素受体增加信号传导,2)增加环磷酸腺苷反应元件结合蛋白的表达,以及3)增加含SRY盒基因11转录因子的表达。