Karin Nathan, Wildbaum Gizi
Department of Immunology & Rappaport Family Institute for Research in the Medical Sciences Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 1 Efron St., P.O.B. 9649, Bat-Galim, Haifa 32000, Israel.
Department of Immunology & Rappaport Family Institute for Research in the Medical Sciences Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 1 Efron St., P.O.B. 9649, Bat-Galim, Haifa 32000, Israel.
Int Immunopharmacol. 2015 Oct;28(2):829-35. doi: 10.1016/j.intimp.2015.03.037. Epub 2015 Apr 20.
Chemokines are small (~8-14 kDa) structurally-related chemotactic cytokines that regulate cell trafficking through interactions with specific seven-trans membrane, G protein-coupled receptors (GPCRs). One of the important features of G protein-coupled receptors (GPCRs) is their ability to transmit diverse signaling cascades upon binding different ligands. The current review focuses on the interplay between three ligands: CXCL9, CXCL10 and CXCL11 binding the same receptor (CXCR3) on CD4+ T cells, yet direct different signaling cascades to shape T cell mediated immunity. The review brings about a new concept regarding the biological activities of chemokines in shaping CD4+ T cell immunity, and also a new approach for applying chemokine based therapy of autoimmune diseases.
趋化因子是一类结构相关的小分子（约8-14千道尔顿）趋化性细胞因子，它们通过与特定的七跨膜G蛋白偶联受体（GPCR）相互作用来调节细胞迁移。G蛋白偶联受体（GPCR）的一个重要特征是，它们在结合不同配体时能够传递多种信号级联反应。本综述聚焦于三种配体之间的相互作用：CXCL9、CXCL10和CXCL11结合CD4+ T细胞上的同一受体（CXCR3），却引导不同的信号级联反应来塑造T细胞介导的免疫。该综述提出了一个关于趋化因子在塑造CD4+ T细胞免疫中的生物学活性的新概念，以及一种基于趋化因子治疗自身免疫性疾病的新方法。
